Abstract
Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.
| Original language | English |
|---|---|
| Pages (from-to) | 86-90 |
| Number of pages | 5 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 5 |
| Issue number | 3 |
| Publication status | Published - 1991 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Physiology (medical)
- Medicine (miscellaneous)
- Physiology
- Agricultural and Biological Sciences(all)
