Negative-regulatory role of calmodulin in the expression of interferon-beta gene

H. Y. Lin, H. R. Thacore

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Addition of the calmodulin-antagonist, trifluoperazine (TFP), to human cell cultures productng biologically active IFN-β in response to Sendai virus, results in a significant increase in IFN-β production. This increase in IFN-β production is observed 1 h after addition of TFP. The increase in IFN-β production is correlated with increase in IFN-β mRNA synthesis. Results suggest that calmodulin or camodulin-dependent cellular process is involved in negative regulation of IFN-β gene.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume5
Issue number3
Publication statusPublished - 1991
Externally publishedYes

Fingerprint

trifluoperazine
interferon-beta
Trifluoperazine
Interferon-beta
calmodulin
Calmodulin
Sendai virus
Genes
antagonists
cell culture
genes
Cell Culture Techniques
Messenger RNA
synthesis

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

Negative-regulatory role of calmodulin in the expression of interferon-beta gene. / Lin, H. Y.; Thacore, H. R.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 5, No. 3, 1991, p. 86-90.

Research output: Contribution to journalArticle

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