Near-infrared mesoporous silica nanoparticles for optical imaging: Characterization and in vivo biodistribution

Chia Hung Lee, Shih Hsun Cheng, Yu Jing Wang, Yu Ching Chen, Nai Tzu Chen, Jeffrey Souris, Chin Tu Chen, Chung Yuan Mou, Chung Shi Yang, Leu Wei Lo

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266 Citations (Scopus)


The characterization of near-infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN-TA) with the average size of 50-100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN-TA-ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN-TA-ICG against pH indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN-TA-ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN-TA-ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN-TA-ICG in major organs. This is the first report of MSN function alized with NIR-ICG capable of optical imaging in vivo.

Original languageEnglish
Pages (from-to)215-222
Number of pages8
JournalAdvanced Functional Materials
Issue number2
Publication statusPublished - Jan 23 2009
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics


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