Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis

Jeng Hsien Yen, Chia Hui Lin, Wen Chun Tsai, Tsan Teng Ou, Cheng Chin Wu, Chaur Jong Hu, Hong Wen Liu

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Objectives: To investigate the association of natural resistance-associated macrophage protein 1 gene (NRAMP1) polymorphisms with rheumatoid arthritis (RA) in Taiwan. Methods: NRAMP1 polymorphisms were determined from 113 RA patients and 74 healthy controls using the polymerase chain reaction/restriction fragment length polymorphism method. Results: The genotype frequencies of NRAMP1 823 C/C, 1703G/G (543D/D), and 1729 + 55 del 4 TGTG+/+ (244/244) were significantly higher in patients with RA than in controls. Similar findings were also evident in allele frequencies and allele carriage frequencies of 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244). The associations of these polymorphisms with RA were independent of HLA-DR4. Linkage disequilibria could be found between 823C and 1703G, and between 1703G and 1729 + 55 del 4 TGTG+. The estimated haplotype frequency of NRAMP1 823C/1703G/1729 + 55 del 4 TGTG+ was significantly increased in RA patients compared with controls. We also found that patients with 823 C/C had a significantly lower prevalence of rheumatoid nodule than those without 823 C/C. Conclusion: NRAMP1 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244) are precipitating factors for the development of RA in Taiwan. The estimated NRAMP1 823C/1703G/1729 + del 4 TGTG+ haplotype is associated with susceptibility to RA. NRAMP1 823 C/C prevents the development of rheumatoid nodule in RA patients.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalImmunology Letters
Issue number1
Publication statusPublished - Jan 15 2006



  • NRAMP1
  • Polymorphism
  • Rheumatoid arthritis
  • SLC11A1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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