Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis

Jeng Hsien Yen, Chia Hui Lin, Wen Chun Tsai, Tsan Teng Ou, Cheng Chin Wu, Chaur Jong Hu, Hong Wen Liu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: To investigate the association of natural resistance-associated macrophage protein 1 gene (NRAMP1) polymorphisms with rheumatoid arthritis (RA) in Taiwan. Methods: NRAMP1 polymorphisms were determined from 113 RA patients and 74 healthy controls using the polymerase chain reaction/restriction fragment length polymorphism method. Results: The genotype frequencies of NRAMP1 823 C/C, 1703G/G (543D/D), and 1729 + 55 del 4 TGTG+/+ (244/244) were significantly higher in patients with RA than in controls. Similar findings were also evident in allele frequencies and allele carriage frequencies of 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244). The associations of these polymorphisms with RA were independent of HLA-DR4. Linkage disequilibria could be found between 823C and 1703G, and between 1703G and 1729 + 55 del 4 TGTG+. The estimated haplotype frequency of NRAMP1 823C/1703G/1729 + 55 del 4 TGTG+ was significantly increased in RA patients compared with controls. We also found that patients with 823 C/C had a significantly lower prevalence of rheumatoid nodule than those without 823 C/C. Conclusion: NRAMP1 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244) are precipitating factors for the development of RA in Taiwan. The estimated NRAMP1 823C/1703G/1729 + del 4 TGTG+ haplotype is associated with susceptibility to RA. NRAMP1 823 C/C prevents the development of rheumatoid nodule in RA patients.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalImmunology Letters
Volume102
Issue number1
DOIs
Publication statusPublished - Jan 15 2006

Fingerprint

tyrosyl-glutamyl-tyrosyl-glutamic acid
Rheumatoid Arthritis
Genes
Rheumatoid Nodule
Taiwan
Gene Frequency
Haplotypes
HLA-DR4 Antigen
Precipitating Factors
natural resistance-associated macrophage protein 1
Linkage Disequilibrium
Restriction Fragment Length Polymorphisms
Genotype

Keywords

  • NRAMP1
  • Polymorphism
  • Rheumatoid arthritis
  • SLC11A1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis. / Yen, Jeng Hsien; Lin, Chia Hui; Tsai, Wen Chun; Ou, Tsan Teng; Wu, Cheng Chin; Hu, Chaur Jong; Liu, Hong Wen.

In: Immunology Letters, Vol. 102, No. 1, 15.01.2006, p. 91-97.

Research output: Contribution to journalArticle

Yen, Jeng Hsien ; Lin, Chia Hui ; Tsai, Wen Chun ; Ou, Tsan Teng ; Wu, Cheng Chin ; Hu, Chaur Jong ; Liu, Hong Wen. / Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis. In: Immunology Letters. 2006 ; Vol. 102, No. 1. pp. 91-97.
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abstract = "Objectives: To investigate the association of natural resistance-associated macrophage protein 1 gene (NRAMP1) polymorphisms with rheumatoid arthritis (RA) in Taiwan. Methods: NRAMP1 polymorphisms were determined from 113 RA patients and 74 healthy controls using the polymerase chain reaction/restriction fragment length polymorphism method. Results: The genotype frequencies of NRAMP1 823 C/C, 1703G/G (543D/D), and 1729 + 55 del 4 TGTG+/+ (244/244) were significantly higher in patients with RA than in controls. Similar findings were also evident in allele frequencies and allele carriage frequencies of 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244). The associations of these polymorphisms with RA were independent of HLA-DR4. Linkage disequilibria could be found between 823C and 1703G, and between 1703G and 1729 + 55 del 4 TGTG+. The estimated haplotype frequency of NRAMP1 823C/1703G/1729 + 55 del 4 TGTG+ was significantly increased in RA patients compared with controls. We also found that patients with 823 C/C had a significantly lower prevalence of rheumatoid nodule than those without 823 C/C. Conclusion: NRAMP1 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244) are precipitating factors for the development of RA in Taiwan. The estimated NRAMP1 823C/1703G/1729 + del 4 TGTG+ haplotype is associated with susceptibility to RA. NRAMP1 823 C/C prevents the development of rheumatoid nodule in RA patients.",
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N2 - Objectives: To investigate the association of natural resistance-associated macrophage protein 1 gene (NRAMP1) polymorphisms with rheumatoid arthritis (RA) in Taiwan. Methods: NRAMP1 polymorphisms were determined from 113 RA patients and 74 healthy controls using the polymerase chain reaction/restriction fragment length polymorphism method. Results: The genotype frequencies of NRAMP1 823 C/C, 1703G/G (543D/D), and 1729 + 55 del 4 TGTG+/+ (244/244) were significantly higher in patients with RA than in controls. Similar findings were also evident in allele frequencies and allele carriage frequencies of 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244). The associations of these polymorphisms with RA were independent of HLA-DR4. Linkage disequilibria could be found between 823C and 1703G, and between 1703G and 1729 + 55 del 4 TGTG+. The estimated haplotype frequency of NRAMP1 823C/1703G/1729 + 55 del 4 TGTG+ was significantly increased in RA patients compared with controls. We also found that patients with 823 C/C had a significantly lower prevalence of rheumatoid nodule than those without 823 C/C. Conclusion: NRAMP1 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244) are precipitating factors for the development of RA in Taiwan. The estimated NRAMP1 823C/1703G/1729 + del 4 TGTG+ haplotype is associated with susceptibility to RA. NRAMP1 823 C/C prevents the development of rheumatoid nodule in RA patients.

AB - Objectives: To investigate the association of natural resistance-associated macrophage protein 1 gene (NRAMP1) polymorphisms with rheumatoid arthritis (RA) in Taiwan. Methods: NRAMP1 polymorphisms were determined from 113 RA patients and 74 healthy controls using the polymerase chain reaction/restriction fragment length polymorphism method. Results: The genotype frequencies of NRAMP1 823 C/C, 1703G/G (543D/D), and 1729 + 55 del 4 TGTG+/+ (244/244) were significantly higher in patients with RA than in controls. Similar findings were also evident in allele frequencies and allele carriage frequencies of 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244). The associations of these polymorphisms with RA were independent of HLA-DR4. Linkage disequilibria could be found between 823C and 1703G, and between 1703G and 1729 + 55 del 4 TGTG+. The estimated haplotype frequency of NRAMP1 823C/1703G/1729 + 55 del 4 TGTG+ was significantly increased in RA patients compared with controls. We also found that patients with 823 C/C had a significantly lower prevalence of rheumatoid nodule than those without 823 C/C. Conclusion: NRAMP1 823C, 1703G (543D), and 1729 + 55 del 4 TGTG+ (244) are precipitating factors for the development of RA in Taiwan. The estimated NRAMP1 823C/1703G/1729 + del 4 TGTG+ haplotype is associated with susceptibility to RA. NRAMP1 823 C/C prevents the development of rheumatoid nodule in RA patients.

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