Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis

Yi Ying Wu, Chia Ching Hsieh, Chia Ying Li, Wen Huei Chang, Jih Jung Chen, Kuei Hung Lai, Zhi Hong Wen, Hsu Ming Chung

Research output: Contribution to journalArticlepeer-review

Abstract

Chemical examination of Sinularia querciformis afforded one new cembranoid, querciformolide F (1), along with four known cembranoids, sinulariolone (2), granosolide A (3), querciformolide A (4), and sinulariolide (5). The structures of these compounds were determined by extensive spectroscopic (IR, ESIMS, 1H NMR, and 13C NMR) analysis and by comparison with those previously reported in the literature. Compounds 2 to 4 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

Original languageEnglish
JournalNatural Product Communications
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 2021

Keywords

  • antiinflammatory
  • cembrane
  • diterpenoid
  • sinularia querciformis
  • soft coral

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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