Nationwide surveillance of antimicrobial resistance among non-fermentative Gram-negative bacteria in Intensive Care Units in Taiwan: SMART programme data 2005

Shio Shin Jean, Po Ren Hsueh, Wen Sen Lee, Hou Tai Chang, Ming Yuan Chou, Ing Shen Chen, Jen Hsien Wang, Chen Fu Lin, Jainn Ming Shyr, Wen Chien Ko, Jiunn Jong Wu, Yung Ching Liu, Wen Kuei Huang, Lee Jene Teng, Cheng Yi Liu

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A nationwide surveillance of the antimicrobial susceptibilities of glucose non-fermentative Gram-negative bacteria isolates was conducted from 1 September 2005 to 30 November 2005 in Taiwan. A total of 456 isolates were recovered from patients hospitalised in the Intensive Care Units (ICUs) of ten major teaching hospitals. Rates of resistant pathogens, such as ciprofloxacin-resistant Pseudomonas aeruginosa (19%) and imipenem-resistant Acinetobacter baumannii (25%), were higher than those reported in 2000 (8% and 22%, respectively). Increased rates of isolates with resistant phenotypes correlated with prolonged length of ICU stay (48 h to ≤7 days vs. >7 days) for ceftazidime-non-susceptible P. aeruginosa (20.0% and 29.7%, respectively), imipenem-non-susceptible P. aeruginosa (4.0% and 13.5%, respectively) and imipenem-non-susceptible A. baumannii (15.4% and 29.8%, respectively), but not for ciprofloxacin-resistant P. aeruginosa. Alarming rates of emergence of extensively drug-resistant (XDR) A. baumannii (15%) and XDR P. aeruginosa (1.8%) were found, particularly among those isolates that were not susceptible to tigecycline and colistin. Interhospital dissemination of some clones of XDR A. baumannii in different ICUs was also noted. This study illustrates the crucial nature of continuous nationwide surveillance of resistant pathogens and implementation of effective strategies for ICU infection control and antibiotic restriction.

Original languageEnglish
Pages (from-to)266-271
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 2009
Externally publishedYes

Fingerprint

Acinetobacter baumannii
Gram-Negative Bacteria
Taiwan
Pseudomonas aeruginosa
Intensive Care Units
Imipenem
Ciprofloxacin
Colistin
Ceftazidime
Infection Control
Teaching Hospitals
Clone Cells
Anti-Bacterial Agents
Phenotype
Glucose
Pharmaceutical Preparations

Keywords

  • Colistin
  • Extensively drug-resistant
  • Non-fermentative Gram-negative bacteria
  • Surveillance
  • Susceptibility
  • Tigecycline

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Nationwide surveillance of antimicrobial resistance among non-fermentative Gram-negative bacteria in Intensive Care Units in Taiwan : SMART programme data 2005. / Jean, Shio Shin; Hsueh, Po Ren; Lee, Wen Sen; Chang, Hou Tai; Chou, Ming Yuan; Chen, Ing Shen; Wang, Jen Hsien; Lin, Chen Fu; Shyr, Jainn Ming; Ko, Wen Chien; Wu, Jiunn Jong; Liu, Yung Ching; Huang, Wen Kuei; Teng, Lee Jene; Liu, Cheng Yi.

In: International Journal of Antimicrobial Agents, Vol. 33, No. 3, 03.2009, p. 266-271.

Research output: Contribution to journalArticle

Jean, Shio Shin ; Hsueh, Po Ren ; Lee, Wen Sen ; Chang, Hou Tai ; Chou, Ming Yuan ; Chen, Ing Shen ; Wang, Jen Hsien ; Lin, Chen Fu ; Shyr, Jainn Ming ; Ko, Wen Chien ; Wu, Jiunn Jong ; Liu, Yung Ching ; Huang, Wen Kuei ; Teng, Lee Jene ; Liu, Cheng Yi. / Nationwide surveillance of antimicrobial resistance among non-fermentative Gram-negative bacteria in Intensive Care Units in Taiwan : SMART programme data 2005. In: International Journal of Antimicrobial Agents. 2009 ; Vol. 33, No. 3. pp. 266-271.
@article{d691661b27fe4fb0afa957d6eb83f888,
title = "Nationwide surveillance of antimicrobial resistance among non-fermentative Gram-negative bacteria in Intensive Care Units in Taiwan: SMART programme data 2005",
abstract = "A nationwide surveillance of the antimicrobial susceptibilities of glucose non-fermentative Gram-negative bacteria isolates was conducted from 1 September 2005 to 30 November 2005 in Taiwan. A total of 456 isolates were recovered from patients hospitalised in the Intensive Care Units (ICUs) of ten major teaching hospitals. Rates of resistant pathogens, such as ciprofloxacin-resistant Pseudomonas aeruginosa (19{\%}) and imipenem-resistant Acinetobacter baumannii (25{\%}), were higher than those reported in 2000 (8{\%} and 22{\%}, respectively). Increased rates of isolates with resistant phenotypes correlated with prolonged length of ICU stay (48 h to ≤7 days vs. >7 days) for ceftazidime-non-susceptible P. aeruginosa (20.0{\%} and 29.7{\%}, respectively), imipenem-non-susceptible P. aeruginosa (4.0{\%} and 13.5{\%}, respectively) and imipenem-non-susceptible A. baumannii (15.4{\%} and 29.8{\%}, respectively), but not for ciprofloxacin-resistant P. aeruginosa. Alarming rates of emergence of extensively drug-resistant (XDR) A. baumannii (15{\%}) and XDR P. aeruginosa (1.8{\%}) were found, particularly among those isolates that were not susceptible to tigecycline and colistin. Interhospital dissemination of some clones of XDR A. baumannii in different ICUs was also noted. This study illustrates the crucial nature of continuous nationwide surveillance of resistant pathogens and implementation of effective strategies for ICU infection control and antibiotic restriction.",
keywords = "Colistin, Extensively drug-resistant, Non-fermentative Gram-negative bacteria, Surveillance, Susceptibility, Tigecycline",
author = "Jean, {Shio Shin} and Hsueh, {Po Ren} and Lee, {Wen Sen} and Chang, {Hou Tai} and Chou, {Ming Yuan} and Chen, {Ing Shen} and Wang, {Jen Hsien} and Lin, {Chen Fu} and Shyr, {Jainn Ming} and Ko, {Wen Chien} and Wu, {Jiunn Jong} and Liu, {Yung Ching} and Huang, {Wen Kuei} and Teng, {Lee Jene} and Liu, {Cheng Yi}",
year = "2009",
month = "3",
doi = "10.1016/j.ijantimicag.2008.08.026",
language = "English",
volume = "33",
pages = "266--271",
journal = "International Journal of Antimicrobial Agents",
issn = "0924-8579",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Nationwide surveillance of antimicrobial resistance among non-fermentative Gram-negative bacteria in Intensive Care Units in Taiwan

T2 - SMART programme data 2005

AU - Jean, Shio Shin

AU - Hsueh, Po Ren

AU - Lee, Wen Sen

AU - Chang, Hou Tai

AU - Chou, Ming Yuan

AU - Chen, Ing Shen

AU - Wang, Jen Hsien

AU - Lin, Chen Fu

AU - Shyr, Jainn Ming

AU - Ko, Wen Chien

AU - Wu, Jiunn Jong

AU - Liu, Yung Ching

AU - Huang, Wen Kuei

AU - Teng, Lee Jene

AU - Liu, Cheng Yi

PY - 2009/3

Y1 - 2009/3

N2 - A nationwide surveillance of the antimicrobial susceptibilities of glucose non-fermentative Gram-negative bacteria isolates was conducted from 1 September 2005 to 30 November 2005 in Taiwan. A total of 456 isolates were recovered from patients hospitalised in the Intensive Care Units (ICUs) of ten major teaching hospitals. Rates of resistant pathogens, such as ciprofloxacin-resistant Pseudomonas aeruginosa (19%) and imipenem-resistant Acinetobacter baumannii (25%), were higher than those reported in 2000 (8% and 22%, respectively). Increased rates of isolates with resistant phenotypes correlated with prolonged length of ICU stay (48 h to ≤7 days vs. >7 days) for ceftazidime-non-susceptible P. aeruginosa (20.0% and 29.7%, respectively), imipenem-non-susceptible P. aeruginosa (4.0% and 13.5%, respectively) and imipenem-non-susceptible A. baumannii (15.4% and 29.8%, respectively), but not for ciprofloxacin-resistant P. aeruginosa. Alarming rates of emergence of extensively drug-resistant (XDR) A. baumannii (15%) and XDR P. aeruginosa (1.8%) were found, particularly among those isolates that were not susceptible to tigecycline and colistin. Interhospital dissemination of some clones of XDR A. baumannii in different ICUs was also noted. This study illustrates the crucial nature of continuous nationwide surveillance of resistant pathogens and implementation of effective strategies for ICU infection control and antibiotic restriction.

AB - A nationwide surveillance of the antimicrobial susceptibilities of glucose non-fermentative Gram-negative bacteria isolates was conducted from 1 September 2005 to 30 November 2005 in Taiwan. A total of 456 isolates were recovered from patients hospitalised in the Intensive Care Units (ICUs) of ten major teaching hospitals. Rates of resistant pathogens, such as ciprofloxacin-resistant Pseudomonas aeruginosa (19%) and imipenem-resistant Acinetobacter baumannii (25%), were higher than those reported in 2000 (8% and 22%, respectively). Increased rates of isolates with resistant phenotypes correlated with prolonged length of ICU stay (48 h to ≤7 days vs. >7 days) for ceftazidime-non-susceptible P. aeruginosa (20.0% and 29.7%, respectively), imipenem-non-susceptible P. aeruginosa (4.0% and 13.5%, respectively) and imipenem-non-susceptible A. baumannii (15.4% and 29.8%, respectively), but not for ciprofloxacin-resistant P. aeruginosa. Alarming rates of emergence of extensively drug-resistant (XDR) A. baumannii (15%) and XDR P. aeruginosa (1.8%) were found, particularly among those isolates that were not susceptible to tigecycline and colistin. Interhospital dissemination of some clones of XDR A. baumannii in different ICUs was also noted. This study illustrates the crucial nature of continuous nationwide surveillance of resistant pathogens and implementation of effective strategies for ICU infection control and antibiotic restriction.

KW - Colistin

KW - Extensively drug-resistant

KW - Non-fermentative Gram-negative bacteria

KW - Surveillance

KW - Susceptibility

KW - Tigecycline

UR - http://www.scopus.com/inward/record.url?scp=60249097030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60249097030&partnerID=8YFLogxK

U2 - 10.1016/j.ijantimicag.2008.08.026

DO - 10.1016/j.ijantimicag.2008.08.026

M3 - Article

C2 - 19091522

AN - SCOPUS:60249097030

VL - 33

SP - 266

EP - 271

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - 3

ER -