Nationwide surveillance of antimicrobial resistance among haemophilus influenzae and streptococcus pneumoniae in intensive care units in Taiwan

S. S. Jean, P. R. Hsueh, W. S. Lee, H. T. Chang, M. Y. Chou, I. S. Chen, J. H. Wang, C. F. Lin, J. M. Shyr, W. C. Ko, J. J. Wu, Y. C. Liu, W. K. Huang, L. J. Teng, C. Y. Liu

Research output: Contribution to journalArticle

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Abstract

A nationwide susceptibility surveillance of Streptococcus pneumoniae and Haemophilus influenzae isolates collected from patients treated at the intensive care units (ICUs) of ten Taiwanese major teaching hospitals was conducted from September 2005 through November 2005. High rates of resistance (intermediate/resistant) of S. pneumoniae to penicillin (85% resistance), ceftriaxone (46%/20%), and cefepime (43%/15%) by meningitis criteria, and in contrast, non-susceptibilities (intermediate/resistant) to penicillin (0%/0%), ceftriaxone (20%/0%) and cefepime (15%/0%) by non-meningitis criteria were noted (p values <0.05) by the Clinical and Laboratory Standards Institute 2008. Resistant rate of S. pneumoniae to azithromycin was also high (63%). S. pneumoniae isolates were significantly more susceptible to ertapenem (87%) than to imipenem (39%) and meropenem (44%) (p values <0.05). Rates of non-susceptibilities of H. influenzae isolates to ampicillin and cefaclor were high (55% and 45%, respectively). No β-lactamase-negative ampicillin-resistant (BLNAR) H. influenzae isolates were found. Imipenem has a notably higher MIC90 value (8 μg/ml) for H. influenzae than that of the other two carbapenems. Tigecycline showed good in vitro activities against these two respiratory pathogens. High rates of resistance among isolates of S. pneumoniae and H. influenzae continue to exist in the ICUs of Taiwan.

Original languageEnglish
Pages (from-to)1013-1017
Number of pages5
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume28
Issue number8
DOIs
Publication statusPublished - Aug 2009
Externally publishedYes

Fingerprint

Haemophilus influenzae
Streptococcus pneumoniae
Taiwan
Intensive Care Units
Ceftriaxone
Imipenem
meropenem
Ampicillin
Cefaclor
Penicillin Resistance
Azithromycin
Carbapenems
Meningitis
Teaching Hospitals
Penicillins
cefepime

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Nationwide surveillance of antimicrobial resistance among haemophilus influenzae and streptococcus pneumoniae in intensive care units in Taiwan. / Jean, S. S.; Hsueh, P. R.; Lee, W. S.; Chang, H. T.; Chou, M. Y.; Chen, I. S.; Wang, J. H.; Lin, C. F.; Shyr, J. M.; Ko, W. C.; Wu, J. J.; Liu, Y. C.; Huang, W. K.; Teng, L. J.; Liu, C. Y.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 28, No. 8, 08.2009, p. 1013-1017.

Research output: Contribution to journalArticle

Jean, S. S. ; Hsueh, P. R. ; Lee, W. S. ; Chang, H. T. ; Chou, M. Y. ; Chen, I. S. ; Wang, J. H. ; Lin, C. F. ; Shyr, J. M. ; Ko, W. C. ; Wu, J. J. ; Liu, Y. C. ; Huang, W. K. ; Teng, L. J. ; Liu, C. Y. / Nationwide surveillance of antimicrobial resistance among haemophilus influenzae and streptococcus pneumoniae in intensive care units in Taiwan. In: European Journal of Clinical Microbiology and Infectious Diseases. 2009 ; Vol. 28, No. 8. pp. 1013-1017.
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abstract = "A nationwide susceptibility surveillance of Streptococcus pneumoniae and Haemophilus influenzae isolates collected from patients treated at the intensive care units (ICUs) of ten Taiwanese major teaching hospitals was conducted from September 2005 through November 2005. High rates of resistance (intermediate/resistant) of S. pneumoniae to penicillin (85{\%} resistance), ceftriaxone (46{\%}/20{\%}), and cefepime (43{\%}/15{\%}) by meningitis criteria, and in contrast, non-susceptibilities (intermediate/resistant) to penicillin (0{\%}/0{\%}), ceftriaxone (20{\%}/0{\%}) and cefepime (15{\%}/0{\%}) by non-meningitis criteria were noted (p values <0.05) by the Clinical and Laboratory Standards Institute 2008. Resistant rate of S. pneumoniae to azithromycin was also high (63{\%}). S. pneumoniae isolates were significantly more susceptible to ertapenem (87{\%}) than to imipenem (39{\%}) and meropenem (44{\%}) (p values <0.05). Rates of non-susceptibilities of H. influenzae isolates to ampicillin and cefaclor were high (55{\%} and 45{\%}, respectively). No β-lactamase-negative ampicillin-resistant (BLNAR) H. influenzae isolates were found. Imipenem has a notably higher MIC90 value (8 μg/ml) for H. influenzae than that of the other two carbapenems. Tigecycline showed good in vitro activities against these two respiratory pathogens. High rates of resistance among isolates of S. pneumoniae and H. influenzae continue to exist in the ICUs of Taiwan.",
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AU - Jean, S. S.

AU - Hsueh, P. R.

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AU - Chang, H. T.

AU - Chou, M. Y.

AU - Chen, I. S.

AU - Wang, J. H.

AU - Lin, C. F.

AU - Shyr, J. M.

AU - Ko, W. C.

AU - Wu, J. J.

AU - Liu, Y. C.

AU - Huang, W. K.

AU - Teng, L. J.

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N2 - A nationwide susceptibility surveillance of Streptococcus pneumoniae and Haemophilus influenzae isolates collected from patients treated at the intensive care units (ICUs) of ten Taiwanese major teaching hospitals was conducted from September 2005 through November 2005. High rates of resistance (intermediate/resistant) of S. pneumoniae to penicillin (85% resistance), ceftriaxone (46%/20%), and cefepime (43%/15%) by meningitis criteria, and in contrast, non-susceptibilities (intermediate/resistant) to penicillin (0%/0%), ceftriaxone (20%/0%) and cefepime (15%/0%) by non-meningitis criteria were noted (p values <0.05) by the Clinical and Laboratory Standards Institute 2008. Resistant rate of S. pneumoniae to azithromycin was also high (63%). S. pneumoniae isolates were significantly more susceptible to ertapenem (87%) than to imipenem (39%) and meropenem (44%) (p values <0.05). Rates of non-susceptibilities of H. influenzae isolates to ampicillin and cefaclor were high (55% and 45%, respectively). No β-lactamase-negative ampicillin-resistant (BLNAR) H. influenzae isolates were found. Imipenem has a notably higher MIC90 value (8 μg/ml) for H. influenzae than that of the other two carbapenems. Tigecycline showed good in vitro activities against these two respiratory pathogens. High rates of resistance among isolates of S. pneumoniae and H. influenzae continue to exist in the ICUs of Taiwan.

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