Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan

S. S. Jean, P. R. Hsueh, W. S. Lee, H. T. Chang, M. Y. Chou, I. S. Chen, J. H. Wang, C. F. Lin, J. M. Shyr, W. C. Ko, J. J. Wu, Y. C. Liu, W. K. Huang, L. J. Teng, C. Y. Liu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To determine the antimicrobial resistance profiles among clinical isolates of Enterobacteriaceae in Taiwanese intensive care units (ICUs), a national surveillance of antibiotic resistance among important Enterobacteriaceae was conducted from September 2005 through November 2005 at the ICUs of ten major teaching hospitals in Taiwan. A total of 574 Enterobacteriaceae isolates recovered from various clinical samples of our ICU patients were submitted for in vitro test. Minimum inhibitory concentrations (MICs) of these isolates to 18 antimicrobial agents were determined by the broth microdilution method. The prevalences of Enterobacteriaceae isolates with phenotypic extended-spectrum β-lactamase (ESBL) production were 26% in Klebsiella pneumoniae, 16% in Serratia marcescens, 14% in Escherichia coli, and 13% in Proteus mirabilis, in which a significantly rising prevalence of ESBL production among K. pneumoniae was noted (p∈=∈0.002) when compared with a previous Taiwanese survey in 2000. Heterogeneous resistance to various fluoroquinolones was found among our Enterobacteriaceae isolates, except for Entetrobacter cloacae. Emergence of ertapenem-resistant isolates of E. coli, K. pneumoniae, E. cloacae, and S. marcescens was noted. Gradually increasing rates of drug-resistant Enterobacteriaceae were noted in Taiwanese ICUs. Periodic surveillance of the evolutionary trend of antimicrobial resistance among ICU isolates is crucial for starting appropriately empirical antimicrobial therapy in the future.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

Fingerprint

Enterobacteriaceae
Taiwan
Intensive Care Units
Klebsiella pneumoniae
Cloaca
Serratia marcescens
Escherichia coli
Proteus mirabilis
Fluoroquinolones
Microbial Sensitivity Tests
Microbial Drug Resistance
Anti-Infective Agents
Teaching Hospitals
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan. / Jean, S. S.; Hsueh, P. R.; Lee, W. S.; Chang, H. T.; Chou, M. Y.; Chen, I. S.; Wang, J. H.; Lin, C. F.; Shyr, J. M.; Ko, W. C.; Wu, J. J.; Liu, Y. C.; Huang, W. K.; Teng, L. J.; Liu, C. Y.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 28, No. 2, 02.2009, p. 215-220.

Research output: Contribution to journalArticle

Jean, S. S. ; Hsueh, P. R. ; Lee, W. S. ; Chang, H. T. ; Chou, M. Y. ; Chen, I. S. ; Wang, J. H. ; Lin, C. F. ; Shyr, J. M. ; Ko, W. C. ; Wu, J. J. ; Liu, Y. C. ; Huang, W. K. ; Teng, L. J. ; Liu, C. Y. / Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan. In: European Journal of Clinical Microbiology and Infectious Diseases. 2009 ; Vol. 28, No. 2. pp. 215-220.
@article{bad50ef920f546fd800ac18ef7e312f2,
title = "Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan",
abstract = "To determine the antimicrobial resistance profiles among clinical isolates of Enterobacteriaceae in Taiwanese intensive care units (ICUs), a national surveillance of antibiotic resistance among important Enterobacteriaceae was conducted from September 2005 through November 2005 at the ICUs of ten major teaching hospitals in Taiwan. A total of 574 Enterobacteriaceae isolates recovered from various clinical samples of our ICU patients were submitted for in vitro test. Minimum inhibitory concentrations (MICs) of these isolates to 18 antimicrobial agents were determined by the broth microdilution method. The prevalences of Enterobacteriaceae isolates with phenotypic extended-spectrum β-lactamase (ESBL) production were 26{\%} in Klebsiella pneumoniae, 16{\%} in Serratia marcescens, 14{\%} in Escherichia coli, and 13{\%} in Proteus mirabilis, in which a significantly rising prevalence of ESBL production among K. pneumoniae was noted (p∈=∈0.002) when compared with a previous Taiwanese survey in 2000. Heterogeneous resistance to various fluoroquinolones was found among our Enterobacteriaceae isolates, except for Entetrobacter cloacae. Emergence of ertapenem-resistant isolates of E. coli, K. pneumoniae, E. cloacae, and S. marcescens was noted. Gradually increasing rates of drug-resistant Enterobacteriaceae were noted in Taiwanese ICUs. Periodic surveillance of the evolutionary trend of antimicrobial resistance among ICU isolates is crucial for starting appropriately empirical antimicrobial therapy in the future.",
author = "Jean, {S. S.} and Hsueh, {P. R.} and Lee, {W. S.} and Chang, {H. T.} and Chou, {M. Y.} and Chen, {I. S.} and Wang, {J. H.} and Lin, {C. F.} and Shyr, {J. M.} and Ko, {W. C.} and Wu, {J. J.} and Liu, {Y. C.} and Huang, {W. K.} and Teng, {L. J.} and Liu, {C. Y.}",
year = "2009",
month = "2",
doi = "10.1007/s10096-008-0610-7",
language = "English",
volume = "28",
pages = "215--220",
journal = "European Journal of Clinical Microbiology and Infectious Diseases",
issn = "0934-9723",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Nationwide surveillance of antimicrobial resistance among Enterobacteriaceae in intensive care units in Taiwan

AU - Jean, S. S.

AU - Hsueh, P. R.

AU - Lee, W. S.

AU - Chang, H. T.

AU - Chou, M. Y.

AU - Chen, I. S.

AU - Wang, J. H.

AU - Lin, C. F.

AU - Shyr, J. M.

AU - Ko, W. C.

AU - Wu, J. J.

AU - Liu, Y. C.

AU - Huang, W. K.

AU - Teng, L. J.

AU - Liu, C. Y.

PY - 2009/2

Y1 - 2009/2

N2 - To determine the antimicrobial resistance profiles among clinical isolates of Enterobacteriaceae in Taiwanese intensive care units (ICUs), a national surveillance of antibiotic resistance among important Enterobacteriaceae was conducted from September 2005 through November 2005 at the ICUs of ten major teaching hospitals in Taiwan. A total of 574 Enterobacteriaceae isolates recovered from various clinical samples of our ICU patients were submitted for in vitro test. Minimum inhibitory concentrations (MICs) of these isolates to 18 antimicrobial agents were determined by the broth microdilution method. The prevalences of Enterobacteriaceae isolates with phenotypic extended-spectrum β-lactamase (ESBL) production were 26% in Klebsiella pneumoniae, 16% in Serratia marcescens, 14% in Escherichia coli, and 13% in Proteus mirabilis, in which a significantly rising prevalence of ESBL production among K. pneumoniae was noted (p∈=∈0.002) when compared with a previous Taiwanese survey in 2000. Heterogeneous resistance to various fluoroquinolones was found among our Enterobacteriaceae isolates, except for Entetrobacter cloacae. Emergence of ertapenem-resistant isolates of E. coli, K. pneumoniae, E. cloacae, and S. marcescens was noted. Gradually increasing rates of drug-resistant Enterobacteriaceae were noted in Taiwanese ICUs. Periodic surveillance of the evolutionary trend of antimicrobial resistance among ICU isolates is crucial for starting appropriately empirical antimicrobial therapy in the future.

AB - To determine the antimicrobial resistance profiles among clinical isolates of Enterobacteriaceae in Taiwanese intensive care units (ICUs), a national surveillance of antibiotic resistance among important Enterobacteriaceae was conducted from September 2005 through November 2005 at the ICUs of ten major teaching hospitals in Taiwan. A total of 574 Enterobacteriaceae isolates recovered from various clinical samples of our ICU patients were submitted for in vitro test. Minimum inhibitory concentrations (MICs) of these isolates to 18 antimicrobial agents were determined by the broth microdilution method. The prevalences of Enterobacteriaceae isolates with phenotypic extended-spectrum β-lactamase (ESBL) production were 26% in Klebsiella pneumoniae, 16% in Serratia marcescens, 14% in Escherichia coli, and 13% in Proteus mirabilis, in which a significantly rising prevalence of ESBL production among K. pneumoniae was noted (p∈=∈0.002) when compared with a previous Taiwanese survey in 2000. Heterogeneous resistance to various fluoroquinolones was found among our Enterobacteriaceae isolates, except for Entetrobacter cloacae. Emergence of ertapenem-resistant isolates of E. coli, K. pneumoniae, E. cloacae, and S. marcescens was noted. Gradually increasing rates of drug-resistant Enterobacteriaceae were noted in Taiwanese ICUs. Periodic surveillance of the evolutionary trend of antimicrobial resistance among ICU isolates is crucial for starting appropriately empirical antimicrobial therapy in the future.

UR - http://www.scopus.com/inward/record.url?scp=59449104482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59449104482&partnerID=8YFLogxK

U2 - 10.1007/s10096-008-0610-7

DO - 10.1007/s10096-008-0610-7

M3 - Article

VL - 28

SP - 215

EP - 220

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

SN - 0934-9723

IS - 2

ER -