Nationwide surveillance in Taiwan of the in-vitro activity of tigecycline against clinical isolates of extended-spectrum β-lactamase-producing Enterobacteriaceae

Chin Te Lu, Yin Ching Chuang, Wu Sun, Yung Ching Liu, Yu Jen Cheng, Po Liang Lu, Chih Ming Chen, Gwo Jong Hsu, Tsrang Neng Jang, Chun Ming Lee, Ping Cherng Chiang, Zhi Yuan Shi, Lih Shinn Wang, Hsiang Chi Kung, Hsiu Chen Lin, Chun Hsing Liao, Jien Wei Liu, Cheng Hua Huang, Shih Ming Tsao, Po Ren Hsueh

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10 Citations (Scopus)

Abstract

Tigecycline In-vitro Surveillance in Taiwan (TIST), initiated in 2006, is a nationwide surveillance programme designed to monitor longitudinally the in-vitro activity of tigecycline against commonly encountered resistant bacteria. This study compared the in-vitro activity of tigecycline against clinical isolates of resistant Gram-negative bacteria determined by the broth microdilution and Etest methods. A total of 622 isolates were collected from patients treated at 20 teaching hospitals. Tigecycline had excellent in-vitro activity against extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (N = 275) with MIC90 0.5 μg/mL and a 99.6% susceptibility rate, and also against ESBL-producing Klebsiella pneumoniae (N = 324) with MIC90 2 μg/mL and a 98.5% susceptibility rate. For ESBL-producing Proteus mirabilis (N = 15) the MIC90 was 4 μg/mL with a 73.3% susceptibility rate. For ESBL-producing Klebsiella oxytoca (N = 8) the MIC50 and MIC90 were 0.5 and 1 μg/mL, respectively, with a 100% susceptibility rate. Limited agreement (

Original languageEnglish
JournalInternational Journal of Antimicrobial Agents
Volume32
Issue numberSUPPL. 3
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Keywords

  • Broth microdilution
  • Enterobacteriaceae
  • Etest
  • Extended-spectrum beta-lactamase
  • Taiwan
  • Tigecycline

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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    Lu, C. T., Chuang, Y. C., Sun, W., Liu, Y. C., Cheng, Y. J., Lu, P. L., Chen, C. M., Hsu, G. J., Jang, T. N., Lee, C. M., Chiang, P. C., Shi, Z. Y., Wang, L. S., Kung, H. C., Lin, H. C., Liao, C. H., Liu, J. W., Huang, C. H., Tsao, S. M., & Hsueh, P. R. (2008). Nationwide surveillance in Taiwan of the in-vitro activity of tigecycline against clinical isolates of extended-spectrum β-lactamase-producing Enterobacteriaceae. International Journal of Antimicrobial Agents, 32(SUPPL. 3). https://doi.org/10.1016/S0924-8579(08)70024-4