National Taiwan University Hospital Pilot Study of Chemoradiotherapy for Esophageal Carcinoma

雷 德, 黃 昭源, 丁 禮莉(Lai-Lei Ting), 王 博民, 鍾 娜娜, 陳 斯榮

Research output: Contribution to journalArticle

Abstract

Introduction: Chemoradiotherapy has demonstrated efficacy in esophageal cancer but with poor result. Combined ehemo-radiotherapy and surgery may further increase the local control rate. A pilot study was initiated by using low dose continuous infusion (CI) of 5-FU and daily low dose cisplatin (CDDP) injection with radiotherapy (RT) followed by surgery in patients with locoregional squamous cell carcinoma of the esophagus. Methods: The treatment consisted of RT to the esophagus 5000 cGy in 4 weeks, CI of 5-FU (225 mg/m^2/day) over 28 days and CDDP (6mg/m^2/day) iv injection 30 minutes before RT. Patients were then restaged by esophagogram, panendoscopy and CT scan. Esophagectomy will be performed on approximately three to five weeks after completion of concurrent chemoradiotherapy.Results: From October 1993 to August 1994, 13 men and 3 women were en rolled. All were evaluated for toxicity and response. The median age was 62 years old, the median pretreatment weight loss was 6 kilograms, and the median serum albumin level was 3.7 gm/dl. Grade III and IV leukopenia were noted in 7 patients and 2 patients, respectively. Three patients had Grade IV thrombocytopenia. Seven patients (44%) showed complete remission on restaging. The 2-year survival rate is 37%.Conclusion: This treatment regimen provides a high local tumor control. However, the toxicity of the treatment was unacceptably high.
Original languageEnglish
Pages (from-to)5-11
Number of pages7
Journal放射治療與腫瘤學
Volume3
Issue number1
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Chemoradiotherapy
Taiwan
Carcinoma
Radiotherapy
Fluorouracil
Esophagus
Injections
Esophagectomy
Leukopenia
Esophageal Neoplasms
Serum Albumin
Thrombocytopenia
Cisplatin
Weight Loss
Squamous Cell Carcinoma
Therapeutics
Survival Rate
Neoplasms

Keywords

  • 食道癌
  • 併用化學治療與放射治療
  • 毒性
  • Esophageal cancer
  • Chemoradiotherapy
  • Toxicity

Cite this

National Taiwan University Hospital Pilot Study of Chemoradiotherapy for Esophageal Carcinoma. / 雷德; 黃昭源; 丁禮莉(Lai-Lei Ting); 王博民; 鍾娜娜; 陳斯榮.

In: 放射治療與腫瘤學, Vol. 3, No. 1, 1996, p. 5-11.

Research output: Contribution to journalArticle

雷德 ; 黃昭源 ; 丁禮莉(Lai-Lei Ting) ; 王博民 ; 鍾娜娜 ; 陳斯榮. / National Taiwan University Hospital Pilot Study of Chemoradiotherapy for Esophageal Carcinoma. In: 放射治療與腫瘤學. 1996 ; Vol. 3, No. 1. pp. 5-11.
@article{8a379a449da349a094a6f87b235dd910,
title = "National Taiwan University Hospital Pilot Study of Chemoradiotherapy for Esophageal Carcinoma",
abstract = "Introduction: Chemoradiotherapy has demonstrated efficacy in esophageal cancer but with poor result. Combined ehemo-radiotherapy and surgery may further increase the local control rate. A pilot study was initiated by using low dose continuous infusion (CI) of 5-FU and daily low dose cisplatin (CDDP) injection with radiotherapy (RT) followed by surgery in patients with locoregional squamous cell carcinoma of the esophagus. Methods: The treatment consisted of RT to the esophagus 5000 cGy in 4 weeks, CI of 5-FU (225 mg/m^2/day) over 28 days and CDDP (6mg/m^2/day) iv injection 30 minutes before RT. Patients were then restaged by esophagogram, panendoscopy and CT scan. Esophagectomy will be performed on approximately three to five weeks after completion of concurrent chemoradiotherapy.Results: From October 1993 to August 1994, 13 men and 3 women were en rolled. All were evaluated for toxicity and response. The median age was 62 years old, the median pretreatment weight loss was 6 kilograms, and the median serum albumin level was 3.7 gm/dl. Grade III and IV leukopenia were noted in 7 patients and 2 patients, respectively. Three patients had Grade IV thrombocytopenia. Seven patients (44{\%}) showed complete remission on restaging. The 2-year survival rate is 37{\%}.Conclusion: This treatment regimen provides a high local tumor control. However, the toxicity of the treatment was unacceptably high.",
keywords = "食道癌, 併用化學治療與放射治療, 毒性, Esophageal cancer, Chemoradiotherapy, Toxicity, Esophageal cancer, Chemoradiotherapy, Toxicity",
author = "德 雷 and 昭源 黃 and 丁, {禮莉(Lai-Lei Ting)} and 博民 王 and 娜娜 鍾 and 斯榮 陳",
year = "1996",
doi = "10.6316/TRO/199603",
language = "English",
volume = "3",
pages = "5--11",
journal = "放射治療與腫瘤學",
issn = "1023-988x",
publisher = "台灣放射腫瘤學會",
number = "1",

}

TY - JOUR

T1 - National Taiwan University Hospital Pilot Study of Chemoradiotherapy for Esophageal Carcinoma

AU - 雷, 德

AU - 黃, 昭源

AU - 丁, 禮莉(Lai-Lei Ting)

AU - 王, 博民

AU - 鍾, 娜娜

AU - 陳, 斯榮

PY - 1996

Y1 - 1996

N2 - Introduction: Chemoradiotherapy has demonstrated efficacy in esophageal cancer but with poor result. Combined ehemo-radiotherapy and surgery may further increase the local control rate. A pilot study was initiated by using low dose continuous infusion (CI) of 5-FU and daily low dose cisplatin (CDDP) injection with radiotherapy (RT) followed by surgery in patients with locoregional squamous cell carcinoma of the esophagus. Methods: The treatment consisted of RT to the esophagus 5000 cGy in 4 weeks, CI of 5-FU (225 mg/m^2/day) over 28 days and CDDP (6mg/m^2/day) iv injection 30 minutes before RT. Patients were then restaged by esophagogram, panendoscopy and CT scan. Esophagectomy will be performed on approximately three to five weeks after completion of concurrent chemoradiotherapy.Results: From October 1993 to August 1994, 13 men and 3 women were en rolled. All were evaluated for toxicity and response. The median age was 62 years old, the median pretreatment weight loss was 6 kilograms, and the median serum albumin level was 3.7 gm/dl. Grade III and IV leukopenia were noted in 7 patients and 2 patients, respectively. Three patients had Grade IV thrombocytopenia. Seven patients (44%) showed complete remission on restaging. The 2-year survival rate is 37%.Conclusion: This treatment regimen provides a high local tumor control. However, the toxicity of the treatment was unacceptably high.

AB - Introduction: Chemoradiotherapy has demonstrated efficacy in esophageal cancer but with poor result. Combined ehemo-radiotherapy and surgery may further increase the local control rate. A pilot study was initiated by using low dose continuous infusion (CI) of 5-FU and daily low dose cisplatin (CDDP) injection with radiotherapy (RT) followed by surgery in patients with locoregional squamous cell carcinoma of the esophagus. Methods: The treatment consisted of RT to the esophagus 5000 cGy in 4 weeks, CI of 5-FU (225 mg/m^2/day) over 28 days and CDDP (6mg/m^2/day) iv injection 30 minutes before RT. Patients were then restaged by esophagogram, panendoscopy and CT scan. Esophagectomy will be performed on approximately three to five weeks after completion of concurrent chemoradiotherapy.Results: From October 1993 to August 1994, 13 men and 3 women were en rolled. All were evaluated for toxicity and response. The median age was 62 years old, the median pretreatment weight loss was 6 kilograms, and the median serum albumin level was 3.7 gm/dl. Grade III and IV leukopenia were noted in 7 patients and 2 patients, respectively. Three patients had Grade IV thrombocytopenia. Seven patients (44%) showed complete remission on restaging. The 2-year survival rate is 37%.Conclusion: This treatment regimen provides a high local tumor control. However, the toxicity of the treatment was unacceptably high.

KW - 食道癌

KW - 併用化學治療與放射治療

KW - 毒性

KW - Esophageal cancer

KW - Chemoradiotherapy

KW - Toxicity

KW - Esophageal cancer

KW - Chemoradiotherapy

KW - Toxicity

UR - http://www.airitilibrary.com/Publication/alDetailedMesh?DocID=1023988x-199603-3-1-5-11-a

U2 - 10.6316/TRO/199603

DO - 10.6316/TRO/199603

M3 - Article

VL - 3

SP - 5

EP - 11

JO - 放射治療與腫瘤學

JF - 放射治療與腫瘤學

SN - 1023-988x

IS - 1

ER -