National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

Yu Chia Hsieh, Pen Yi Lin, Cheng Hsun Chiu, Yhu Chering Huang, Kuang Yi Chang, Chun Hsing Liao, Nan Chang Chiu, Yin Ching Chuang, Po Yen Chen, Shan Chwen Chang, Jien Wei Liu, Muh Yong Yen, Jen Hsien Wang, Cheng Yi Liu, Tzou Yien Lin

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ≤5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95% CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ≤5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed.

Original languageEnglish
Pages (from-to)5513-5518
Number of pages6
JournalVaccine
Volume27
Issue number40
DOIs
Publication statusPublished - Sep 4 2009
Externally publishedYes

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national surveys
Taiwan
Pneumococcal Vaccines
serotypes
Vaccination
vaccination
vaccines
Conjugate Vaccines
Streptococcus pneumoniae
Serogroup
Surveys and Questionnaires
polysaccharides
incidence
monitoring
Incidence
Population

Keywords

  • Invasive pneumococcal diseases
  • Invasive potential
  • Serotype 19A

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007 : Emergence of serotype 19A with high invasive potential. / Hsieh, Yu Chia; Lin, Pen Yi; Chiu, Cheng Hsun; Huang, Yhu Chering; Chang, Kuang Yi; Liao, Chun Hsing; Chiu, Nan Chang; Chuang, Yin Ching; Chen, Po Yen; Chang, Shan Chwen; Liu, Jien Wei; Yen, Muh Yong; Wang, Jen Hsien; Liu, Cheng Yi; Lin, Tzou Yien.

In: Vaccine, Vol. 27, No. 40, 04.09.2009, p. 5513-5518.

Research output: Contribution to journalArticle

Hsieh, YC, Lin, PY, Chiu, CH, Huang, YC, Chang, KY, Liao, CH, Chiu, NC, Chuang, YC, Chen, PY, Chang, SC, Liu, JW, Yen, MY, Wang, JH, Liu, CY & Lin, TY 2009, 'National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential', Vaccine, vol. 27, no. 40, pp. 5513-5518. https://doi.org/10.1016/j.vaccine.2009.06.091
Hsieh, Yu Chia ; Lin, Pen Yi ; Chiu, Cheng Hsun ; Huang, Yhu Chering ; Chang, Kuang Yi ; Liao, Chun Hsing ; Chiu, Nan Chang ; Chuang, Yin Ching ; Chen, Po Yen ; Chang, Shan Chwen ; Liu, Jien Wei ; Yen, Muh Yong ; Wang, Jen Hsien ; Liu, Cheng Yi ; Lin, Tzou Yien. / National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007 : Emergence of serotype 19A with high invasive potential. In: Vaccine. 2009 ; Vol. 27, No. 40. pp. 5513-5518.
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abstract = "We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ≤5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95{\%} CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ≤5 years, serotypes 14 (OR, 17.3; 95{\%} CI, 5.2-57.9) and 19A (OR, 14.9; 95{\%} CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73{\%} of cases in children aged between 2 and 4 years, and 64.7{\%} of cases in children aged <2 years. Among patients aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4{\%} of cases. In the future, a broader pneumococcal vaccine is needed.",
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AU - Huang, Yhu Chering

AU - Chang, Kuang Yi

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