NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan

Hui Ling Chiou, Ming Fang Wu, Wen Pin Chien, Ya Wen Cheng, Ruey Hong Wong, Chin Yi Chen, Torng Sen Lin, Huei Lee

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The correlation between cooking oil fumes, containing relatively higher amounts of heterocyclic amines, and female lung cancer has been revealed. The association of genetic polymorphisms of CYP1A2 and NAT2, two major enzymes responsible for the metabolism of heterocyclic amines, with lung cancer has been investigated with inconclusive results. In this study targeted on never-smoking population with 162 lung cancer patients and 208 non-cancer controls, while the distributions of CYP1A2 phenotypes in lung cancer patients were comparable to that in controls, NAT2 fast acetylators had an OR of 2.44 (95% CI 1.40-4.23, P=0.002) and 2.56 (95% CI 1.37-4.80, P=0.003) for lung cancer in overall and female cases, respectively, but not in males. These results suggested never-smoking females with NAT2 fast acetylator were more prone to lung cancer and reflected the possibility that exposure to heterocyclic amines may contribute to the female lung cancer development in Taiwan.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalCancer Letters
Volume223
Issue number1
DOIs
Publication statusPublished - Jun 1 2005
Externally publishedYes

Keywords

  • CYP1A2
  • Females
  • Lung cancer
  • NAT2
  • Never-smoking

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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