NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan

Chi Chou Huang, Wen Pin Chien, Ruey Hong Wong, Ya Wen Cheng, Meng Cheng Chen, Ming Chih Chou, Huei Lee

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19 Citations (Scopus)

Abstract

In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and colorectal cancer risk is not clearly understood. We conducted a study with 244 primary colorectal cancer cases and 299 cancer-free healthy control subjects to verify the association of NAT2 polymorphisms with the risk of Taiwanese colorectal cancer. Our data showed that subjects with the NAT2 W/W homozygous genotype had a 1.63-fold increased risk of colorectal cancer compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.03-2.58); however, no risk was found in the W/Mx heterozygous and Mx/W+W/W fast acetylator genotypes. Being stratified by gender factors, the colorectal cancer risk in females with homozygous W/W or Mx/W+W/W fast acetylators increased 2.47-fold and 2.13-fold compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.27-4.82 for W/W genotype; 95 percent confidence interval, 1.17-3.89 for Mx/W+W/W genotype); however, the risk of the NAT2 genotype and colorectal cancer was not observed in males. Collectively, patients with the NAT2 fast acetylator genotype were more prone to colorectal cancer and reflected the possibility that exposure to heterocyclic amines may contribute to colorectal cancer development in Taiwan, especially in Taiwanese females.

Original languageEnglish
Pages (from-to)981-989
Number of pages9
JournalDiseases of the Colon & Rectum
Volume50
Issue number7
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Keywords

  • Colorectal cancer
  • N-acetyltransferase 2

ASJC Scopus subject areas

  • Gastroenterology

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    Huang, C. C., Chien, W. P., Wong, R. H., Cheng, Y. W., Chen, M. C., Chou, M. C., & Lee, H. (2007). NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan. Diseases of the Colon & Rectum, 50(7), 981-989. https://doi.org/10.1007/s10350-007-0230-9