NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan

Chi Chou Huang, Wen Pin Chien, Ruey Hong Wong, Ya Wen Cheng, Meng Cheng Chen, Ming Chih Chou, Huei Lee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and colorectal cancer risk is not clearly understood. We conducted a study with 244 primary colorectal cancer cases and 299 cancer-free healthy control subjects to verify the association of NAT2 polymorphisms with the risk of Taiwanese colorectal cancer. Our data showed that subjects with the NAT2 W/W homozygous genotype had a 1.63-fold increased risk of colorectal cancer compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.03-2.58); however, no risk was found in the W/Mx heterozygous and Mx/W+W/W fast acetylator genotypes. Being stratified by gender factors, the colorectal cancer risk in females with homozygous W/W or Mx/W+W/W fast acetylators increased 2.47-fold and 2.13-fold compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.27-4.82 for W/W genotype; 95 percent confidence interval, 1.17-3.89 for Mx/W+W/W genotype); however, the risk of the NAT2 genotype and colorectal cancer was not observed in males. Collectively, patients with the NAT2 fast acetylator genotype were more prone to colorectal cancer and reflected the possibility that exposure to heterocyclic amines may contribute to colorectal cancer development in Taiwan, especially in Taiwanese females.

Original languageEnglish
Pages (from-to)981-989
Number of pages9
JournalDiseases of the Colon & Rectum
Volume50
Issue number7
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Fingerprint

Acetyltransferases
Taiwan
Colorectal Neoplasms
Genotype
Confidence Intervals
Amines
Incidence
Meat
Healthy Volunteers

Keywords

  • Colorectal cancer
  • N-acetyltransferase 2

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Huang, C. C., Chien, W. P., Wong, R. H., Cheng, Y. W., Chen, M. C., Chou, M. C., & Lee, H. (2007). NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan. Diseases of the Colon & Rectum, 50(7), 981-989. https://doi.org/10.1007/s10350-007-0230-9

NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan. / Huang, Chi Chou; Chien, Wen Pin; Wong, Ruey Hong; Cheng, Ya Wen; Chen, Meng Cheng; Chou, Ming Chih; Lee, Huei.

In: Diseases of the Colon & Rectum, Vol. 50, No. 7, 07.2007, p. 981-989.

Research output: Contribution to journalArticle

Huang, CC, Chien, WP, Wong, RH, Cheng, YW, Chen, MC, Chou, MC & Lee, H 2007, 'NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan', Diseases of the Colon & Rectum, vol. 50, no. 7, pp. 981-989. https://doi.org/10.1007/s10350-007-0230-9
Huang, Chi Chou ; Chien, Wen Pin ; Wong, Ruey Hong ; Cheng, Ya Wen ; Chen, Meng Cheng ; Chou, Ming Chih ; Lee, Huei. / NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan. In: Diseases of the Colon & Rectum. 2007 ; Vol. 50, No. 7. pp. 981-989.
@article{125815e3f1684247bf9ac43089f8683c,
title = "NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan",
abstract = "In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and colorectal cancer risk is not clearly understood. We conducted a study with 244 primary colorectal cancer cases and 299 cancer-free healthy control subjects to verify the association of NAT2 polymorphisms with the risk of Taiwanese colorectal cancer. Our data showed that subjects with the NAT2 W/W homozygous genotype had a 1.63-fold increased risk of colorectal cancer compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.03-2.58); however, no risk was found in the W/Mx heterozygous and Mx/W+W/W fast acetylator genotypes. Being stratified by gender factors, the colorectal cancer risk in females with homozygous W/W or Mx/W+W/W fast acetylators increased 2.47-fold and 2.13-fold compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.27-4.82 for W/W genotype; 95 percent confidence interval, 1.17-3.89 for Mx/W+W/W genotype); however, the risk of the NAT2 genotype and colorectal cancer was not observed in males. Collectively, patients with the NAT2 fast acetylator genotype were more prone to colorectal cancer and reflected the possibility that exposure to heterocyclic amines may contribute to colorectal cancer development in Taiwan, especially in Taiwanese females.",
keywords = "Colorectal cancer, N-acetyltransferase 2",
author = "Huang, {Chi Chou} and Chien, {Wen Pin} and Wong, {Ruey Hong} and Cheng, {Ya Wen} and Chen, {Meng Cheng} and Chou, {Ming Chih} and Huei Lee",
year = "2007",
month = "7",
doi = "10.1007/s10350-007-0230-9",
language = "English",
volume = "50",
pages = "981--989",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan

AU - Huang, Chi Chou

AU - Chien, Wen Pin

AU - Wong, Ruey Hong

AU - Cheng, Ya Wen

AU - Chen, Meng Cheng

AU - Chou, Ming Chih

AU - Lee, Huei

PY - 2007/7

Y1 - 2007/7

N2 - In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and colorectal cancer risk is not clearly understood. We conducted a study with 244 primary colorectal cancer cases and 299 cancer-free healthy control subjects to verify the association of NAT2 polymorphisms with the risk of Taiwanese colorectal cancer. Our data showed that subjects with the NAT2 W/W homozygous genotype had a 1.63-fold increased risk of colorectal cancer compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.03-2.58); however, no risk was found in the W/Mx heterozygous and Mx/W+W/W fast acetylator genotypes. Being stratified by gender factors, the colorectal cancer risk in females with homozygous W/W or Mx/W+W/W fast acetylators increased 2.47-fold and 2.13-fold compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.27-4.82 for W/W genotype; 95 percent confidence interval, 1.17-3.89 for Mx/W+W/W genotype); however, the risk of the NAT2 genotype and colorectal cancer was not observed in males. Collectively, patients with the NAT2 fast acetylator genotype were more prone to colorectal cancer and reflected the possibility that exposure to heterocyclic amines may contribute to colorectal cancer development in Taiwan, especially in Taiwanese females.

AB - In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and colorectal cancer risk is not clearly understood. We conducted a study with 244 primary colorectal cancer cases and 299 cancer-free healthy control subjects to verify the association of NAT2 polymorphisms with the risk of Taiwanese colorectal cancer. Our data showed that subjects with the NAT2 W/W homozygous genotype had a 1.63-fold increased risk of colorectal cancer compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.03-2.58); however, no risk was found in the W/Mx heterozygous and Mx/W+W/W fast acetylator genotypes. Being stratified by gender factors, the colorectal cancer risk in females with homozygous W/W or Mx/W+W/W fast acetylators increased 2.47-fold and 2.13-fold compared with those with the Mx/Mx slow acetylator genotype (95 percent confidence interval, 1.27-4.82 for W/W genotype; 95 percent confidence interval, 1.17-3.89 for Mx/W+W/W genotype); however, the risk of the NAT2 genotype and colorectal cancer was not observed in males. Collectively, patients with the NAT2 fast acetylator genotype were more prone to colorectal cancer and reflected the possibility that exposure to heterocyclic amines may contribute to colorectal cancer development in Taiwan, especially in Taiwanese females.

KW - Colorectal cancer

KW - N-acetyltransferase 2

UR - http://www.scopus.com/inward/record.url?scp=34447108942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447108942&partnerID=8YFLogxK

U2 - 10.1007/s10350-007-0230-9

DO - 10.1007/s10350-007-0230-9

M3 - Article

VL - 50

SP - 981

EP - 989

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 7

ER -