Abstract
We applied a multiplex polymerase chain reaction (PCR) and culture to detect Streptococcus pneumoniae and detected 3 other respiratory pathogens Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis simultaneously by PCR, in the nasopharynx of 386 children aged under 5 y. S. pneumoniae was the most common pathogen carried by children in all age groups, with the rate ranging from 15.8% in children aged 34 y to 28.6% in children aged 23 y. H. influenzae and M. catarrhalis showed similar carriage rates across all the age groups. Only 2 young children (0.5%) carried A. otitidis. Higher carriage of S. pneumoniae was found in children who had not received the heptavalent pneumococcal conjugate vaccine (PCV7). Cefotaxime non-susceptibility was high (51.4%) in S. pneumoniae nasopharyngeal isolates. Serotype 6B was the most common in fully immunized carriers and also in those who received catch-up immunization. Due to low PCV7 coverage in Taiwan, the carriage of vaccine and non-vaccine serotypes of S. pneumoniae in children remains common.
| Original language | English |
|---|---|
| Pages (from-to) | 937-942 |
| Number of pages | 6 |
| Journal | Scandinavian Journal of Infectious Diseases |
| Volume | 43 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - Dec 2011 |
| Externally published | Yes |
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Keywords
- Children
- Nasopharyngeal carriage
- Pneumococcal conjugate vaccine
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
- Microbiology (medical)
- Infectious Diseases
Cite this
Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis in young children in the era of pneumococcal immunization, Taiwan. / Janapatla, Rajendra Prasad; Chang, Hsin Ju; Hsu, Mei Hua; Hsieh, Yu Chia; Lin, Tzou Yien; Chiu, Cheng Hsun.
In: Scandinavian Journal of Infectious Diseases, Vol. 43, No. 11-12, 12.2011, p. 937-942.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis in young children in the era of pneumococcal immunization, Taiwan
AU - Janapatla, Rajendra Prasad
AU - Chang, Hsin Ju
AU - Hsu, Mei Hua
AU - Hsieh, Yu Chia
AU - Lin, Tzou Yien
AU - Chiu, Cheng Hsun
PY - 2011/12
Y1 - 2011/12
N2 - We applied a multiplex polymerase chain reaction (PCR) and culture to detect Streptococcus pneumoniae and detected 3 other respiratory pathogens Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis simultaneously by PCR, in the nasopharynx of 386 children aged under 5 y. S. pneumoniae was the most common pathogen carried by children in all age groups, with the rate ranging from 15.8% in children aged 34 y to 28.6% in children aged 23 y. H. influenzae and M. catarrhalis showed similar carriage rates across all the age groups. Only 2 young children (0.5%) carried A. otitidis. Higher carriage of S. pneumoniae was found in children who had not received the heptavalent pneumococcal conjugate vaccine (PCV7). Cefotaxime non-susceptibility was high (51.4%) in S. pneumoniae nasopharyngeal isolates. Serotype 6B was the most common in fully immunized carriers and also in those who received catch-up immunization. Due to low PCV7 coverage in Taiwan, the carriage of vaccine and non-vaccine serotypes of S. pneumoniae in children remains common.
AB - We applied a multiplex polymerase chain reaction (PCR) and culture to detect Streptococcus pneumoniae and detected 3 other respiratory pathogens Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis simultaneously by PCR, in the nasopharynx of 386 children aged under 5 y. S. pneumoniae was the most common pathogen carried by children in all age groups, with the rate ranging from 15.8% in children aged 34 y to 28.6% in children aged 23 y. H. influenzae and M. catarrhalis showed similar carriage rates across all the age groups. Only 2 young children (0.5%) carried A. otitidis. Higher carriage of S. pneumoniae was found in children who had not received the heptavalent pneumococcal conjugate vaccine (PCV7). Cefotaxime non-susceptibility was high (51.4%) in S. pneumoniae nasopharyngeal isolates. Serotype 6B was the most common in fully immunized carriers and also in those who received catch-up immunization. Due to low PCV7 coverage in Taiwan, the carriage of vaccine and non-vaccine serotypes of S. pneumoniae in children remains common.
KW - Children
KW - Nasopharyngeal carriage
KW - Pneumococcal conjugate vaccine
UR - http://www.scopus.com/inward/record.url?scp=80755130160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80755130160&partnerID=8YFLogxK
U2 - 10.3109/00365548.2011.601754
DO - 10.3109/00365548.2011.601754
M3 - Article
VL - 43
SP - 937
EP - 942
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 11-12
ER -