Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis in young children in the era of pneumococcal immunization, Taiwan

Rajendra Prasad Janapatla, Hsin Ju Chang, Mei Hua Hsu, Yu Chia Hsieh, Tzou Yien Lin, Cheng Hsun Chiu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We applied a multiplex polymerase chain reaction (PCR) and culture to detect Streptococcus pneumoniae and detected 3 other respiratory pathogens Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis simultaneously by PCR, in the nasopharynx of 386 children aged under 5 y. S. pneumoniae was the most common pathogen carried by children in all age groups, with the rate ranging from 15.8% in children aged 34 y to 28.6% in children aged 23 y. H. influenzae and M. catarrhalis showed similar carriage rates across all the age groups. Only 2 young children (0.5%) carried A. otitidis. Higher carriage of S. pneumoniae was found in children who had not received the heptavalent pneumococcal conjugate vaccine (PCV7). Cefotaxime non-susceptibility was high (51.4%) in S. pneumoniae nasopharyngeal isolates. Serotype 6B was the most common in fully immunized carriers and also in those who received catch-up immunization. Due to low PCV7 coverage in Taiwan, the carriage of vaccine and non-vaccine serotypes of S. pneumoniae in children remains common.

Original languageEnglish
Pages (from-to)937-942
Number of pages6
JournalScandinavian Journal of Infectious Diseases
Volume43
Issue number11-12
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Fingerprint

Moraxella (Branhamella) catarrhalis
Haemophilus influenzae
Streptococcus pneumoniae
Taiwan
Immunization
Age Groups
Nasopharynx
Cefotaxime
Multiplex Polymerase Chain Reaction
Vaccines
Polymerase Chain Reaction

Keywords

  • Children
  • Nasopharyngeal carriage
  • Pneumococcal conjugate vaccine

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Alloiococcus otitidis in young children in the era of pneumococcal immunization, Taiwan. / Janapatla, Rajendra Prasad; Chang, Hsin Ju; Hsu, Mei Hua; Hsieh, Yu Chia; Lin, Tzou Yien; Chiu, Cheng Hsun.

In: Scandinavian Journal of Infectious Diseases, Vol. 43, No. 11-12, 12.2011, p. 937-942.

Research output: Contribution to journalArticle

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