Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally-administered rats with CCl4-induced acute liver failure

Feng Lin Yen, Tzu Hui Wu, Liang Tzung Lin, Thau Ming Cham, Chun Ching Lin

Research output: Contribution to journalArticle

129 Citations (Scopus)


Purpose: A novel naringenin-loaded nanoparticles system (NARN) was developed to resolve the restricted bioavailability of naringenin (NAR) and to enhance its hepatoprotective effects in vivo on oral administration. Materials and methods: Physicochemical characterizations of NARN included assessment of particle size and morphology, powder X-ray diffraction, fourier transform infrared spectroscopy, and dissolution study. In addition, to evaluate its bioactivities and its oral treatment potential against liver injuries, we compared the hepatoprotective, antioxidant, and antiapoptotic effects of NARN and NAR on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Results: NARN had a significantly higher release rate than NAR and improved its solubility. NARN also exhibited more liver-protective effects compared to NAR with considerable reduction in liver function index and lipid peroxidation, in conjunction to a substantial increase in the levels of the antioxidant enzymes (P∈

Original languageEnglish
Pages (from-to)893-902
Number of pages10
JournalPharmaceutical Research
Issue number4
Publication statusPublished - Apr 2009
Externally publishedYes



  • Antiapoptotic
  • Antioxidant
  • Naringenin-loaded nanoparticles
  • Oral administration
  • Physicochemical characterization

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Organic Chemistry
  • Molecular Medicine
  • Pharmacology (medical)
  • Biotechnology
  • Pharmacology

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