Naphthoflavones as antiproliferative agents: Design, synthesis and biological evaluation

Dinesh Kumar, Onkar Singh, Kunal Nepali, P. M.S. Bedi, Arem Qayum, Shashank Singh, Subheet K. Jain

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The present study involves the design and synthesis of naphthoflavones as antiproliferative agents. The strategy presents naphthoflavones as hybrids of naphthyl based chalcones and flavones. A panel of human cancer cell lines were employed for the cytotoxicity studies. DK-13 exhibited significant cytoxicity against MiaPaCa-2 cell lines with IC50 value of 1.93 μM and 5.63 μM against MCF-7 cell lines. The compound DK-13 was found to induce apoptosis evidenced through phase contrast microscopy, DAPI staining, and mitochondrial membrane potential loss. The cell phase distribution studies indicated an increase from 11.26% (control sample) to 55.19% (sample treated with 20 μM compound DK-13) in the apoptotic population.

Original languageEnglish
Pages (from-to)881-890
Number of pages10
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume16
Issue number7
DOIs
Publication statusPublished - Jul 1 2016
Externally publishedYes

Keywords

  • Apoptosis
  • Cell lines
  • Cytotoxicity
  • Design
  • Naphthoflavones

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Cancer Research

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