Abstract
The present study involves the design and synthesis of naphthoflavones as antiproliferative agents. The strategy presents naphthoflavones as hybrids of naphthyl based chalcones and flavones. A panel of human cancer cell lines were employed for the cytotoxicity studies. DK-13 exhibited significant cytoxicity against MiaPaCa-2 cell lines with IC50 value of 1.93 μM and 5.63 μM against MCF-7 cell lines. The compound DK-13 was found to induce apoptosis evidenced through phase contrast microscopy, DAPI staining, and mitochondrial membrane potential loss. The cell phase distribution studies indicated an increase from 11.26% (control sample) to 55.19% (sample treated with 20 μM compound DK-13) in the apoptotic population.
Original language | English |
---|---|
Pages (from-to) | 881-890 |
Number of pages | 10 |
Journal | Anti-Cancer Agents in Medicinal Chemistry |
Volume | 16 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 1 2016 |
Externally published | Yes |
Keywords
- Apoptosis
- Cell lines
- Cytotoxicity
- Design
- Naphthoflavones
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Cancer Research