Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation

Chi Chang Wu, Fu Hsiang Ko, Ting Siang Su, Bo Syuan Li, Wen Fa Wu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.

Original languageEnglish
Title of host publicationINEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings
Pages872-873
Number of pages2
DOIs
Publication statusPublished - 2010
Externally publishedYes
Event2010 3rd International Nanoelectronics Conference, INEC 2010 - Hongkong, China
Duration: Jan 3 2010Jan 8 2010

Other

Other2010 3rd International Nanoelectronics Conference, INEC 2010
CountryChina
CityHongkong
Period1/3/101/8/10

Fingerprint

Surface cleaning
Field effect transistors
Nanowires
Labels
Genes
Acetone
Ethanol
Fluorescence microscopy
Silicon oxides
Sensors
Sulfuric acid
Hydrogen peroxide
Surface tension
DNA
Fabrication

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Wu, C. C., Ko, F. H., Su, T. S., Li, B. S., & Wu, W. F. (2010). Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. In INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings (pp. 872-873). [5425155] https://doi.org/10.1109/INEC.2010.5425155

Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. / Wu, Chi Chang; Ko, Fu Hsiang; Su, Ting Siang; Li, Bo Syuan; Wu, Wen Fa.

INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings. 2010. p. 872-873 5425155.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wu, CC, Ko, FH, Su, TS, Li, BS & Wu, WF 2010, Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. in INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings., 5425155, pp. 872-873, 2010 3rd International Nanoelectronics Conference, INEC 2010, Hongkong, China, 1/3/10. https://doi.org/10.1109/INEC.2010.5425155
Wu CC, Ko FH, Su TS, Li BS, Wu WF. Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. In INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings. 2010. p. 872-873. 5425155 https://doi.org/10.1109/INEC.2010.5425155
Wu, Chi Chang ; Ko, Fu Hsiang ; Su, Ting Siang ; Li, Bo Syuan ; Wu, Wen Fa. / Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings. 2010. pp. 872-873
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