Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation

Chi Chang Wu; Fu Hsiang Ko; Ting Siang Su; Bo Syuan Li; Wen Fa Wu

doi:10.1109/INEC.2010.5425155

Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation

Chi Chang Wu, Fu Hsiang Ko, Ting Siang Su, Bo Syuan Li, Wen Fa Wu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.

Original language	English
Title of host publication	INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings
Pages	872-873
Number of pages	2
DOIs	https://doi.org/10.1109/INEC.2010.5425155
Publication status	Published - 2010
Externally published	Yes
Event	2010 3rd International Nanoelectronics Conference, INEC 2010 - Hongkong, China Duration: Jan 3 2010 → Jan 8 2010

Other

Other	2010 3rd International Nanoelectronics Conference, INEC 2010
Country	China
City	Hongkong
Period	1/3/10 → 1/8/10

ASJC Scopus subject areas

Electrical and Electronic Engineering

Access to Document

10.1109/INEC.2010.5425155

Fingerprint Dive into the research topics of 'Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation'. Together they form a unique fingerprint.

Cite this

Wu, C. C., Ko, F. H., Su, T. S., Li, B. S., & Wu, W. F. (2010). Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. In INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings (pp. 872-873). [5425155] https://doi.org/10.1109/INEC.2010.5425155

Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. / Wu, Chi Chang; Ko, Fu Hsiang; Su, Ting Siang; Li, Bo Syuan; Wu, Wen Fa.

INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings. 2010. p. 872-873 5425155.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wu, CC, Ko, FH, Su, TS, Li, BS & Wu, WF 2010, Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. in INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings., 5425155, pp. 872-873, 2010 3rd International Nanoelectronics Conference, INEC 2010, Hongkong, China, 1/3/10. https://doi.org/10.1109/INEC.2010.5425155

@inproceedings{a31d85b4d5654e08a22e44a66b705f65,

title = "Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation",

abstract = "We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.",

author = "Wu, {Chi Chang} and Ko, {Fu Hsiang} and Su, {Ting Siang} and Li, {Bo Syuan} and Wu, {Wen Fa}",

year = "2010",

doi = "10.1109/INEC.2010.5425155",

language = "English",

isbn = "9781424435449",

pages = "872--873",

booktitle = "INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings",

note = "2010 3rd International Nanoelectronics Conference, INEC 2010 ; Conference date: 03-01-2010 Through 08-01-2010",

}

TY - GEN

T1 - Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation

AU - Wu, Chi Chang

AU - Ko, Fu Hsiang

AU - Su, Ting Siang

AU - Li, Bo Syuan

AU - Wu, Wen Fa

PY - 2010

Y1 - 2010

N2 - We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.

AB - We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.

UR - http://www.scopus.com/inward/record.url?scp=77951660138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951660138&partnerID=8YFLogxK

U2 - 10.1109/INEC.2010.5425155

DO - 10.1109/INEC.2010.5425155

M3 - Conference contribution

AN - SCOPUS:77951660138

SN - 9781424435449

SP - 872

EP - 873

BT - INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings

T2 - 2010 3rd International Nanoelectronics Conference, INEC 2010

Y2 - 3 January 2010 through 8 January 2010

ER -