Nano/sub-microsized lignan glycosides from sesame meal exhibit higher transport and absorption efficiency in Caco-2 cell monolayer

Chia Ding Liao, Wei Lun Hung, Kuo Ching Jan, An I. Yeh, Chi Tang Ho, Lucy Sun Hwang

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

In the present study, we investigated whether lignan glycosides from sesame meal (LGSM), after nano/sub-microsizing, will exhibit higher transport and absorption efficiencies than LGSM. The average particle size of 1% LGSM aqueous suspension reduced from approximately 2 μm-200 nm after media-milling with zirconia beads. The transport and absorption of LGSM and nano/sub-microsized LGSM (N-LGSM) using Caco-2 human epithelial colorectal adenocarcinoma cells, a model simulating human intestinal absorption was examined. The permeability of sesaminol triglucoside (ST) in N-LGSM and LGSM was 1.41 ± 0.16 and 1.07 ± 0.21 (10-6 cm/s), respectively, indicating that ST in N-LGSM was more efficiently transported through the monolayer. In addition, N-LGSM exhibited 35.7% higher absorption efficiency than LGSM. The better performance of N-LGSM may be attributed to the (a) smaller particle size and larger surface area; (b) increased mucosal permeability, and (c) improved intestinal absorption due to the formation of nanoemulsion droplets.

Original languageEnglish
Pages (from-to)896-902
Number of pages7
JournalFood Chemistry
Volume119
Issue number3
DOIs
Publication statusPublished - Apr 1 2010
Externally publishedYes

Fingerprint

sesame meal
Sesamum
Lignans
Caco-2 Cells
lignans
Glycosides
Meals
glycosides
Monolayers
cells
intestinal absorption
Intestinal Absorption
Particle Size
particle size
Permeability
permeability
Particle size
nanoemulsions
adenocarcinoma
droplets

Keywords

  • Absorption
  • Caco-2 cell monolayer
  • Lignan glycoside
  • Nanotechnology
  • Sesame meal
  • Transport

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science
  • Medicine(all)

Cite this

Nano/sub-microsized lignan glycosides from sesame meal exhibit higher transport and absorption efficiency in Caco-2 cell monolayer. / Liao, Chia Ding; Hung, Wei Lun; Jan, Kuo Ching; Yeh, An I.; Ho, Chi Tang; Hwang, Lucy Sun.

In: Food Chemistry, Vol. 119, No. 3, 01.04.2010, p. 896-902.

Research output: Contribution to journalArticle

Liao, Chia Ding ; Hung, Wei Lun ; Jan, Kuo Ching ; Yeh, An I. ; Ho, Chi Tang ; Hwang, Lucy Sun. / Nano/sub-microsized lignan glycosides from sesame meal exhibit higher transport and absorption efficiency in Caco-2 cell monolayer. In: Food Chemistry. 2010 ; Vol. 119, No. 3. pp. 896-902.
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