Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry

C. W. Tsao, C. H. Lin, Y. C. Cheng, C. C. Chien, C. C. Chang, W. Y. Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry is an established soft ionization method that is widely applied to analyze biomolecules. The UV-absorbing organic matrix is essential for biomolecule ionization; however, it also creates matrix background interference, which results in problematic analyses of biomolecules of less than 700 Da. Therefore, this study investigates hydrophilic, hydrophobic cationic, anionic and immobilized metal ion surface chemical modifications to advance nanostructured silicon mass spectrometry performance (nSi-MS). This investigation provides information required for a possible novel mass spectroscopy that combines surface-enhanced and nanostructured silicon surface-assisted laser desorption/ionization mass spectrometry for the selective detection of specific compounds of a mixture.

Original languageEnglish
Pages (from-to)2643-2650
Number of pages8
JournalAnalyst
Volume137
Issue number11
DOIs
Publication statusPublished - Jun 7 2012

Fingerprint

Silicon
silicon
Ionization
Mass spectrometry
Surface treatment
Desorption
Mass Spectrometry
desorption
Biomolecules
Lasers
ionization
mass spectrometry
laser
matrix
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Chemical modification
Metals
Ions
Metal ions
spectroscopy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Electrochemistry
  • Biochemistry
  • Environmental Chemistry

Cite this

Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry. / Tsao, C. W.; Lin, C. H.; Cheng, Y. C.; Chien, C. C.; Chang, C. C.; Chen, W. Y.

In: Analyst, Vol. 137, No. 11, 07.06.2012, p. 2643-2650.

Research output: Contribution to journalArticle

Tsao, C. W. ; Lin, C. H. ; Cheng, Y. C. ; Chien, C. C. ; Chang, C. C. ; Chen, W. Y. / Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry. In: Analyst. 2012 ; Vol. 137, No. 11. pp. 2643-2650.
@article{cdbfcab1e04e48f0a57a78ddb220ad53,
title = "Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry",
abstract = "Matrix-assisted laser desorption/ionization mass spectrometry is an established soft ionization method that is widely applied to analyze biomolecules. The UV-absorbing organic matrix is essential for biomolecule ionization; however, it also creates matrix background interference, which results in problematic analyses of biomolecules of less than 700 Da. Therefore, this study investigates hydrophilic, hydrophobic cationic, anionic and immobilized metal ion surface chemical modifications to advance nanostructured silicon mass spectrometry performance (nSi-MS). This investigation provides information required for a possible novel mass spectroscopy that combines surface-enhanced and nanostructured silicon surface-assisted laser desorption/ionization mass spectrometry for the selective detection of specific compounds of a mixture.",
author = "Tsao, {C. W.} and Lin, {C. H.} and Cheng, {Y. C.} and Chien, {C. C.} and Chang, {C. C.} and Chen, {W. Y.}",
year = "2012",
month = "6",
day = "7",
doi = "10.1039/c2an35189g",
language = "English",
volume = "137",
pages = "2643--2650",
journal = "The Analyst",
issn = "0003-2654",
publisher = "Royal Society of Chemistry",
number = "11",

}

TY - JOUR

T1 - Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry

AU - Tsao, C. W.

AU - Lin, C. H.

AU - Cheng, Y. C.

AU - Chien, C. C.

AU - Chang, C. C.

AU - Chen, W. Y.

PY - 2012/6/7

Y1 - 2012/6/7

N2 - Matrix-assisted laser desorption/ionization mass spectrometry is an established soft ionization method that is widely applied to analyze biomolecules. The UV-absorbing organic matrix is essential for biomolecule ionization; however, it also creates matrix background interference, which results in problematic analyses of biomolecules of less than 700 Da. Therefore, this study investigates hydrophilic, hydrophobic cationic, anionic and immobilized metal ion surface chemical modifications to advance nanostructured silicon mass spectrometry performance (nSi-MS). This investigation provides information required for a possible novel mass spectroscopy that combines surface-enhanced and nanostructured silicon surface-assisted laser desorption/ionization mass spectrometry for the selective detection of specific compounds of a mixture.

AB - Matrix-assisted laser desorption/ionization mass spectrometry is an established soft ionization method that is widely applied to analyze biomolecules. The UV-absorbing organic matrix is essential for biomolecule ionization; however, it also creates matrix background interference, which results in problematic analyses of biomolecules of less than 700 Da. Therefore, this study investigates hydrophilic, hydrophobic cationic, anionic and immobilized metal ion surface chemical modifications to advance nanostructured silicon mass spectrometry performance (nSi-MS). This investigation provides information required for a possible novel mass spectroscopy that combines surface-enhanced and nanostructured silicon surface-assisted laser desorption/ionization mass spectrometry for the selective detection of specific compounds of a mixture.

UR - http://www.scopus.com/inward/record.url?scp=84864238419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864238419&partnerID=8YFLogxK

U2 - 10.1039/c2an35189g

DO - 10.1039/c2an35189g

M3 - Article

C2 - 22531330

AN - SCOPUS:84864238419

VL - 137

SP - 2643

EP - 2650

JO - The Analyst

JF - The Analyst

SN - 0003-2654

IS - 11

ER -