Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry

C. W. Tsao, C. H. Lin, Y. C. Cheng, C. C. Chien, C. C. Chang, W. Y. Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)


Matrix-assisted laser desorption/ionization mass spectrometry is an established soft ionization method that is widely applied to analyze biomolecules. The UV-absorbing organic matrix is essential for biomolecule ionization; however, it also creates matrix background interference, which results in problematic analyses of biomolecules of less than 700 Da. Therefore, this study investigates hydrophilic, hydrophobic cationic, anionic and immobilized metal ion surface chemical modifications to advance nanostructured silicon mass spectrometry performance (nSi-MS). This investigation provides information required for a possible novel mass spectroscopy that combines surface-enhanced and nanostructured silicon surface-assisted laser desorption/ionization mass spectrometry for the selective detection of specific compounds of a mixture.

Original languageEnglish
Pages (from-to)2643-2650
Number of pages8
Issue number11
Publication statusPublished - Jun 7 2012


ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Electrochemistry
  • Biochemistry
  • Environmental Chemistry

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