Nanostructured lipid carriers (NLCs) for drug delivery and targeting

Chia Lang Fang, Saleh A. Al-Suwayeh, Jia You Fang

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Nanostructured lipid carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. It was shown that NLCs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged half-life, and tissue-targeted delivery. NLCs have attracted increasing attention in recent years. This review describes recent developments in drug delivery using NLCs strategies. The structures, preparation techniques, and physicochemical characterization of NLCs are systematically elucidated in this review. The potential of NLCs to be used for different administration routes is highlighted. Special attention is paid to parenteral injection and topical delivery since these are the most common routes for investigating NLCs. Relevant issues for the introduction of NLCs to market, including pharmaceutical and cosmetic applications, are discussed. The related patents of NLCs for drug delivery are also reviewed. Finally, the future development and current obstacles needing to be resolved are elucidated.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalRecent Patents on Nanotechnology
Volume7
Issue number1
Publication statusPublished - 2013

Fingerprint

Drug delivery
Lipids
lipids
delivery
drugs
routes
Drug Delivery Systems
storage stability
Drug therapy
bioavailability
patents
Cosmetics
chemotherapy
half life
Drug products
permeability
solubility
Solubility
Tissue
injection

Keywords

  • Drug delivery
  • Drug targeting
  • Lipid nanoparticles
  • Nanostructured lipid carriers (NLCs)

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Nanostructured lipid carriers (NLCs) for drug delivery and targeting. / Fang, Chia Lang; Al-Suwayeh, Saleh A.; Fang, Jia You.

In: Recent Patents on Nanotechnology, Vol. 7, No. 1, 2013, p. 41-45.

Research output: Contribution to journalArticle

Fang, Chia Lang ; Al-Suwayeh, Saleh A. ; Fang, Jia You. / Nanostructured lipid carriers (NLCs) for drug delivery and targeting. In: Recent Patents on Nanotechnology. 2013 ; Vol. 7, No. 1. pp. 41-45.
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