Nanoporous materials for biomedical devices

Shashishekar P. Adiga, Larry A. Curtiss, Jeffrey W. Elam, Michael J. Pellin, Chun Che Shih, Chun Ming Shih, Shing Jong Lin, Yea Yang Su, Shaun D. Gittard, Junping Zhang, Roger J. Narayan

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Nandporous materials are currently being developed for use in implantable drug delivery systems, bioartificial organs, and other novel medical devices. Advances in nanofabrication have made it possible to precisely control the pore size, pore distribution, porosity, and chemical properties of pores in nanoporous materials. As a result, these materials are attractive for regulating and sensing transport at the molecular level. In this work, the use of nanoporous membranes for biomedical applications is reviewed. The basic concepts underlying membrane transport are presented in the context of design considerations for efficient size sorting. Desirable properties of nanoporous membranes used in implantable devices, including biocompatibility and antibiofouling behavior are also discussed. In addition, the use of surface modification techniques to improve the function of nanoporous membranes is reviewed. An intriguing possibility involves functionalizing nanoporous materials with smart polymers in order to modulate biomolecular transport in response to pH, temperature, ionic concentration, or other stimuli. These efforts open up avenues to develop smart medical devices that respond to specific physiological conditions.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalJOM
Volume60
Issue number3
DOIs
Publication statusPublished - Mar 2008
Externally publishedYes

Fingerprint

membrane
Membranes
Biocompatibility
Nanotechnology
Sorting
sorting
Chemical properties
Pore size
Surface treatment
chemical property
Polymers
drug
polymer
Porosity
porosity
material
temperature
Temperature
Drug Delivery Systems
distribution

ASJC Scopus subject areas

  • Geochemistry and Petrology
  • Geotechnical Engineering and Engineering Geology
  • Materials Science(all)
  • Metals and Alloys

Cite this

Adiga, S. P., Curtiss, L. A., Elam, J. W., Pellin, M. J., Shih, C. C., Shih, C. M., ... Narayan, R. J. (2008). Nanoporous materials for biomedical devices. JOM, 60(3), 26-32. https://doi.org/10.1007/s11837-008-0028-9

Nanoporous materials for biomedical devices. / Adiga, Shashishekar P.; Curtiss, Larry A.; Elam, Jeffrey W.; Pellin, Michael J.; Shih, Chun Che; Shih, Chun Ming; Lin, Shing Jong; Su, Yea Yang; Gittard, Shaun D.; Zhang, Junping; Narayan, Roger J.

In: JOM, Vol. 60, No. 3, 03.2008, p. 26-32.

Research output: Contribution to journalArticle

Adiga, SP, Curtiss, LA, Elam, JW, Pellin, MJ, Shih, CC, Shih, CM, Lin, SJ, Su, YY, Gittard, SD, Zhang, J & Narayan, RJ 2008, 'Nanoporous materials for biomedical devices', JOM, vol. 60, no. 3, pp. 26-32. https://doi.org/10.1007/s11837-008-0028-9
Adiga SP, Curtiss LA, Elam JW, Pellin MJ, Shih CC, Shih CM et al. Nanoporous materials for biomedical devices. JOM. 2008 Mar;60(3):26-32. https://doi.org/10.1007/s11837-008-0028-9
Adiga, Shashishekar P. ; Curtiss, Larry A. ; Elam, Jeffrey W. ; Pellin, Michael J. ; Shih, Chun Che ; Shih, Chun Ming ; Lin, Shing Jong ; Su, Yea Yang ; Gittard, Shaun D. ; Zhang, Junping ; Narayan, Roger J. / Nanoporous materials for biomedical devices. In: JOM. 2008 ; Vol. 60, No. 3. pp. 26-32.
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