Nanoporous hard carbon membranes for medical applications

Roger J. Narayan, Chunming Jin, Nicola Menegazzo, Boris Mizaikoff, Rosario A. Gerhardt, Melanie Andara, Arvind Agarwal, Chun Che Shih, Chun Ming Shih, Shing Jong Lin, Yea Yang Su

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Current blood glucose sensors have proven to be inadequate for long term in vivo applications; membrane biofouling and inflammation play significant roles in sensor instability. An ideal biosensor membrane material must prevent protein adsorption and promote integration of the sensor with the surrounding tissue. Furthermore, biosensor membranes must be sufficiently thin and porous in order to allow the sensor to rapidly respond to fluctuations in analyte concentration. In this study, the use of diamondlike carbon-coated anodized aluminum oxide as a potential biosensor membrane is discussed. Diamondlike carbon films and diamondlike carbon-coated anodized aluminum oxide nanoporous membranes were examined using scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and platelet rich plasma testing. The diamondlike carbon-coated anodized aluminum oxide membranes remained free from protein adsorption during in vitro platelet rich plasma testing. We anticipate that this novel membrane could find use in immunoisolation devices, pacemakers, kidney dialysis membranes, microdialysis systems, and other devices facing biocompatibility issues that limit in vivo function.

Original languageEnglish
Pages (from-to)1486-1493
Number of pages8
JournalJournal of Nanoscience and Nanotechnology
Volume7
Issue number4-5
DOIs
Publication statusPublished - Apr 2007

Fingerprint

Medical applications
Carbon
Membranes
Aluminum Oxide
Biosensing Techniques
Biosensors
Platelet-Rich Plasma
Platelets
Aluminum
Adsorption
Oxides
Sensors
Biofouling
Dialysis membranes
Glucose sensors
Proteins
Plasmas
Pacemakers
Photoelectron Spectroscopy
Equipment and Supplies

Keywords

  • Biofouling
  • Biosensors
  • Diamondlike carbon
  • Pulsed laser deposition

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Materials Science (miscellaneous)
  • Engineering (miscellaneous)

Cite this

Narayan, R. J., Jin, C., Menegazzo, N., Mizaikoff, B., Gerhardt, R. A., Andara, M., ... Su, Y. Y. (2007). Nanoporous hard carbon membranes for medical applications. Journal of Nanoscience and Nanotechnology, 7(4-5), 1486-1493. https://doi.org/10.1166/jnn.2007.331

Nanoporous hard carbon membranes for medical applications. / Narayan, Roger J.; Jin, Chunming; Menegazzo, Nicola; Mizaikoff, Boris; Gerhardt, Rosario A.; Andara, Melanie; Agarwal, Arvind; Shih, Chun Che; Shih, Chun Ming; Lin, Shing Jong; Su, Yea Yang.

In: Journal of Nanoscience and Nanotechnology, Vol. 7, No. 4-5, 04.2007, p. 1486-1493.

Research output: Contribution to journalArticle

Narayan, RJ, Jin, C, Menegazzo, N, Mizaikoff, B, Gerhardt, RA, Andara, M, Agarwal, A, Shih, CC, Shih, CM, Lin, SJ & Su, YY 2007, 'Nanoporous hard carbon membranes for medical applications', Journal of Nanoscience and Nanotechnology, vol. 7, no. 4-5, pp. 1486-1493. https://doi.org/10.1166/jnn.2007.331
Narayan RJ, Jin C, Menegazzo N, Mizaikoff B, Gerhardt RA, Andara M et al. Nanoporous hard carbon membranes for medical applications. Journal of Nanoscience and Nanotechnology. 2007 Apr;7(4-5):1486-1493. https://doi.org/10.1166/jnn.2007.331
Narayan, Roger J. ; Jin, Chunming ; Menegazzo, Nicola ; Mizaikoff, Boris ; Gerhardt, Rosario A. ; Andara, Melanie ; Agarwal, Arvind ; Shih, Chun Che ; Shih, Chun Ming ; Lin, Shing Jong ; Su, Yea Yang. / Nanoporous hard carbon membranes for medical applications. In: Journal of Nanoscience and Nanotechnology. 2007 ; Vol. 7, No. 4-5. pp. 1486-1493.
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