Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications

Hsiao Lan Pu, Wei Lun Chiang, Barnali Maiti, Zi Xian Liao, Yi Cheng Ho, Min Suk Shim, Er-Tuan Chuang, Younan Xia, Hsing Wen Sung

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Oxidative stress and reduced pH are involved in many inflammatory diseases. This study describes a nanoparticle-based system that is responsive to both oxidative stress and reduced pH in an inflammatory environment to effectively release its encapsulated curcumin, an immune-modulatory agent with potent anti-inflammatory and antioxidant capabilities. Because of the presence of Förster resonance energy transfer between curcumin and the carrier, this system also allowed us to monitor the intracellular release behavior. The curcumin released upon triggering could efficiently reduce the excess oxidants produced by the lipopolysaccharide (LPS)-stimulated macrophages. The feasibility of using the curcumin-loaded nanoparticles for anti-inflammatory applications was further validated in a mouse model with ankle inflammation induced by LPS. The results of these studies demonstrate that the proposed nanoparticle system is promising for treating oxidative stress-related diseases.

Original languageEnglish
Pages (from-to)1213-1221
Number of pages9
JournalACS Nano
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 25 2014
Externally publishedYes

Fingerprint

Curcumin
Oxidative stress
drugs
Anti-Inflammatory Agents
Nanoparticles
nanoparticles
Pharmaceutical Preparations
Lipopolysaccharides
macrophages
Macrophages
antioxidants
wireless communication
Antioxidants
Oxidants
Energy transfer
mice
energy transfer

Keywords

  • anti-inflammation
  • antioxidant
  • drug delivery
  • reactive nitrogen species
  • reactive oxygen species

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Pu, H. L., Chiang, W. L., Maiti, B., Liao, Z. X., Ho, Y. C., Shim, M. S., ... Sung, H. W. (2014). Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications. ACS Nano, 8(2), 1213-1221. https://doi.org/10.1021/nn4058787

Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications. / Pu, Hsiao Lan; Chiang, Wei Lun; Maiti, Barnali; Liao, Zi Xian; Ho, Yi Cheng; Shim, Min Suk; Chuang, Er-Tuan; Xia, Younan; Sung, Hsing Wen.

In: ACS Nano, Vol. 8, No. 2, 25.02.2014, p. 1213-1221.

Research output: Contribution to journalArticle

Pu, HL, Chiang, WL, Maiti, B, Liao, ZX, Ho, YC, Shim, MS, Chuang, E-T, Xia, Y & Sung, HW 2014, 'Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications', ACS Nano, vol. 8, no. 2, pp. 1213-1221. https://doi.org/10.1021/nn4058787
Pu, Hsiao Lan ; Chiang, Wei Lun ; Maiti, Barnali ; Liao, Zi Xian ; Ho, Yi Cheng ; Shim, Min Suk ; Chuang, Er-Tuan ; Xia, Younan ; Sung, Hsing Wen. / Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications. In: ACS Nano. 2014 ; Vol. 8, No. 2. pp. 1213-1221.
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