Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats

Feng Lin Yen, Tzu Hui Wu, Liang Tzung Lin, Thau Ming Cham, Chun Ching Lin

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Cuscuta chinensis is a commonly used traditional Chinese medicine to nourish the liver and kidney. Due to the poor water solubility of its major constituents such as flavonoids and lignans, its absorption upon oral administration could be limited. The purpose of the present study was to use the nanosuspension method to prepare C. chinensis nanoparticles (CN), and to compare the hepatoprotective and antioxidant effects of C. chinensis ethanolic extract (CE) and CN on acetaminophen-induced hepatotoxicity in rats. An oral dose of CE at 125 and 250 mg/kg and CN at 25 and 50 mg/kg showed a significant hepatoprotective effect relatively to the same extent (P <0.05) by reducing levels of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase. These biochemical assessments were supported by rat hepatic biopsy examinations. In addition, the antioxidant activities of CE and CN both significantly increased superoxide dismutase, catalase, glutathione peroxidase, and reduced malondialdehyde (P <0.05). Moreover, the results also indicated that the hepatoprotective and antioxidant effects of 50 mg/kg CN was effectively better than 125 mg/kg CE (P <0.05), and an oral dose of CN that is five times as less as CE could exhibit similar levels of outcomes. In conclusion, we suggest that the nanoparticles system can be applied to overcome other water poorly soluble herbal medicines and furthermore to decrease the treatment dosage.

Original languageEnglish
Pages (from-to)1771-1777
Number of pages7
JournalFood and Chemical Toxicology
Volume46
Issue number5
DOIs
Publication statusPublished - May 2008
Externally publishedYes

Fingerprint

Cuscuta
acetaminophen
hepatotoxicity
nanoparticles
Acetaminophen
Nanoparticles
Rats
rats
extracts
Antioxidants
mouth
dosage
antioxidants
hepatoprotective effect
Lignans
liver
Water
Biopsy
Herbal Medicine
Liver

Keywords

  • Antioxidant
  • Cuscuta chinensis
  • Hepatoprotective
  • Nanoparticles

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats. / Yen, Feng Lin; Wu, Tzu Hui; Lin, Liang Tzung; Cham, Thau Ming; Lin, Chun Ching.

In: Food and Chemical Toxicology, Vol. 46, No. 5, 05.2008, p. 1771-1777.

Research output: Contribution to journalArticle

Yen, Feng Lin ; Wu, Tzu Hui ; Lin, Liang Tzung ; Cham, Thau Ming ; Lin, Chun Ching. / Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats. In: Food and Chemical Toxicology. 2008 ; Vol. 46, No. 5. pp. 1771-1777.
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