Nanoparticle-based immunomagnetic assay of plasma biomarkers for differentiating dementia and prodromal states of Alzheimer's disease – A cross-validation study

Ming Jang Chiu, Ta Fu Chen, Chaur Jong Hu, Sui Hing Yan, Yu Sun, Bing Hsien Liu, Yun Tsui Chang, Che Chuan Yang, Shieh Yueh Yang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Blood-based biomarker assays of plasma β-amyloid (Aβ) and tau have the advantages of cost-effective and less invasive for the diagnosis of Alzheimer's disease (AD). We used two independent cohorts to cross-validate the clinical use of the nanoparticle-based immunomagnetic assay of plasma biomarkers to assist in the differential diagnosis of early AD. There were in total 160 subjects in the derivation cohort, and 242 in the validation cohort both containing controls, mild cognitive impairment due to AD and AD dementia diagnosed according to the 2011 NIA-AA guidelines. The cutoff value for plasma Aβ1–42 (16.4 pg/ml) performed the best in differentiating between controls and patients with prodromal or clinical AD, with 92.5% for positive percent agreement (PPA), negative percent agreement (NPA), and overall rate of agreement (ORA). Aβ1–42 × tau (642.58) was useful for separating patients with dementia and prodromal states of AD, with 84.9% PPA, 78.8% NPA and 83% ORA.

Original languageEnglish
Article number102182
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume28
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Blood-based biomarkers
  • Immunomagnetic reduction assay
  • Mild cognitive impairment
  • Plasma Aβ
  • Plasma tau

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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