Nanofibers used for the delivery of analgesics

Yuan Yun Tseng, Shih Jung Liu

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Nanofibers are extremely advantageous for drug delivery because of their high surface area-to-volume ratios, high porosities and 3D open porous structures. Local delivery of analgesics by using nanofibers allows site-specificity and requires a lower overall drug dosage with lower adverse side effects. Different analgesics have been loaded onto various nanofibers, including those that are natural, synthetic and copolymer, for various medical applications. Analgesics can also be singly or coaxially loaded onto nanofibers to enhance clinical applications. In particular, analgesic-eluting nanofibers provide additional benefits to preventing wound adhesion and scar formation. This paper reviews current research and breakthrough discoveries on the innovative application of analgesic-loaded nanofibers that will alter the clinical therapy of pain.

Original languageEnglish
Pages (from-to)1785-1800
Number of pages16
JournalNanomedicine
Volume10
Issue number11
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • analgesic
  • drug delivery
  • electrospin
  • nanofiber
  • pain
  • polymer

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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