Abstract
Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Food and Chemical Toxicology |
| Volume | 120 |
| DOIs | |
| Publication status | Published - Oct 1 2018 |
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Keywords
- NDAT
- Oral cancer
- PD-L1
- Proliferation
- Thyroxine
ASJC Scopus subject areas
- Food Science
- Toxicology
Cite this
Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. / Lin, Shan Jen; Chin, Yu Tang; Ho, Yih; Chou, Szu Yi; Sh Yang, Yu Chen; Nana, André Wendindondé; Su, Kuan Wei; Lim, Yee Tong; Wang, Kuan; Lee, Sheng‐Yang Y.; Shih, Ya Jung; Chen, Yi Ru; Whang-Peng, Jacqueline; Davis, Paul J.; Lin, Hung Yun; Fu, Earl.
In: Food and Chemical Toxicology, Vol. 120, 01.10.2018, p. 1-11.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells
AU - Lin, Shan Jen
AU - Chin, Yu Tang
AU - Ho, Yih
AU - Chou, Szu Yi
AU - Sh Yang, Yu Chen
AU - Nana, André Wendindondé
AU - Su, Kuan Wei
AU - Lim, Yee Tong
AU - Wang, Kuan
AU - Lee, Sheng‐Yang Y.
AU - Shih, Ya Jung
AU - Chen, Yi Ru
AU - Whang-Peng, Jacqueline
AU - Davis, Paul J.
AU - Lin, Hung Yun
AU - Fu, Earl
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.
AB - Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.
KW - NDAT
KW - Oral cancer
KW - PD-L1
KW - Proliferation
KW - Thyroxine
UR - http://www.scopus.com/inward/record.url?scp=85049344181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049344181&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2018.06.058
DO - 10.1016/j.fct.2018.06.058
M3 - Article
VL - 120
SP - 1
EP - 11
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
SN - 0278-6915
ER -