Abstract

Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalFood and Chemical Toxicology
Volume120
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Mouth Neoplasms
Cells
death
Ligands
phosphatidylinositol 3-kinase
thyroid hormones
tetraiodothyroacetic acid
mouth neoplasms
ligands
neoplasm cells
Phosphatidylinositol 3-Kinases
Thyroid Hormones
Tumors
Neoplasms
Proteins
protein content
Messenger RNA
monitoring

Keywords

  • NDAT
  • Oral cancer
  • PD-L1
  • Proliferation
  • Thyroxine

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. / Lin, Shan Jen; Chin, Yu Tang; Ho, Yih; Chou, Szu Yi; Sh Yang, Yu Chen; Nana, André Wendindondé; Su, Kuan Wei; Lim, Yee Tong; Wang, Kuan; Lee, Sheng‐Yang Y.; Shih, Ya Jung; Chen, Yi Ru; Whang-Peng, Jacqueline; Davis, Paul J.; Lin, Hung Yun; Fu, Earl.

In: Food and Chemical Toxicology, Vol. 120, 01.10.2018, p. 1-11.

Research output: Contribution to journalArticle

Lin, Shan Jen ; Chin, Yu Tang ; Ho, Yih ; Chou, Szu Yi ; Sh Yang, Yu Chen ; Nana, André Wendindondé ; Su, Kuan Wei ; Lim, Yee Tong ; Wang, Kuan ; Lee, Sheng‐Yang Y. ; Shih, Ya Jung ; Chen, Yi Ru ; Whang-Peng, Jacqueline ; Davis, Paul J. ; Lin, Hung Yun ; Fu, Earl. / Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. In: Food and Chemical Toxicology. 2018 ; Vol. 120. pp. 1-11.
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AU - Lee, Sheng‐Yang Y.

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