Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Shan Jen Lin; Yu Tang Chin; Yih Ho; Szu Yi Chou; Yu Chen Sh Yang; André Wendindondé Nana; Kuan Wei Su; Yee Tong Lim; Kuan Wang; Sheng‐Yang Y. Lee; Ya Jung Shih; Yi Ru Chen; Jacqueline Whang-Peng; Paul J. Davis; Hung Yun Lin; Earl Fu

doi:10.1016/j.fct.2018.06.058

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Shan Jen Lin, Yu Tang Chin, Yih Ho, Szu Yi Chou, Yu Chen Sh Yang, André Wendindondé Nana, Kuan Wei Su, Yee Tong Lim, Kuan Wang, Sheng‐Yang Y. Lee, Ya Jung Shih, Yi Ru Chen, Jacqueline Whang-Peng, Paul J. Davis, Hung Yun Lin, Earl Fu

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Food and Chemical Toxicology
Volume	120
DOIs	https://doi.org/10.1016/j.fct.2018.06.058
Publication status	Published - Oct 1 2018

Keywords

NDAT
Oral cancer
PD-L1
Proliferation
Thyroxine

ASJC Scopus subject areas

Food Science
Toxicology

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Lin, S. J., Chin, Y. T., Ho, Y., Chou, S. Y., Sh Yang, Y. C., Nana, A. W., Su, K. W., Lim, Y. T., Wang, K., Lee, SY. Y., Shih, Y. J., Chen, Y. R., Whang-Peng, J., Davis, P. J., Lin, H. Y., & Fu, E. (2018). Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. Food and Chemical Toxicology, 120, 1-11. https://doi.org/10.1016/j.fct.2018.06.058

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. / Lin, Shan Jen; Chin, Yu Tang; Ho, Yih ; Chou, Szu Yi; Sh Yang, Yu Chen; Nana, André Wendindondé; Su, Kuan Wei; Lim, Yee Tong; Wang, Kuan ; Lee, Sheng‐Yang Y.; Shih, Ya Jung; Chen, Yi Ru; Whang-Peng, Jacqueline; Davis, Paul J.; Lin, Hung Yun; Fu, Earl.

In: Food and Chemical Toxicology, Vol. 120, 01.10.2018, p. 1-11.

Research output: Contribution to journal › Article › peer-review

Lin, Shan Jen ; Chin, Yu Tang ; Ho, Yih ; Chou, Szu Yi ; Sh Yang, Yu Chen ; Nana, André Wendindondé ; Su, Kuan Wei ; Lim, Yee Tong ; Wang, Kuan ; Lee, Sheng‐Yang Y. ; Shih, Ya Jung ; Chen, Yi Ru ; Whang-Peng, Jacqueline ; Davis, Paul J. ; Lin, Hung Yun ; Fu, Earl. / Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells. In: Food and Chemical Toxicology. 2018 ; Vol. 120. pp. 1-11.

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abstract = "Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.",

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AU - Nana, André Wendindondé

AU - Su, Kuan Wei

AU - Lim, Yee Tong

AU - Wang, Kuan

AU - Lee, Sheng‐Yang Y.

AU - Shih, Ya Jung

AU - Chen, Yi Ru

AU - Whang-Peng, Jacqueline

AU - Davis, Paul J.

AU - Lin, Hung Yun

AU - Fu, Earl

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AB - Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.

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