Abstract
Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.
Original language | English |
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Pages (from-to) | 1-11 |
Number of pages | 11 |
Journal | Food and Chemical Toxicology |
Volume | 120 |
DOIs | |
Publication status | Published - Oct 1 2018 |
Keywords
- NDAT
- Oral cancer
- PD-L1
- Proliferation
- Thyroxine
ASJC Scopus subject areas
- Food Science
- Toxicology