N-3 Polyunsaturated fatty acids ameliorate cognitive age-related impairments and depressive behaviour in unchallenged aged prediabetic rats

Yu Ru Guo, Yi Hao Hsu, An Liang, Wan Jung Lu, Chi Hao Wu, Hsiu Chuan Lee, Shih Yi Huang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Epidemiological studies have reported that nutritional deficit of n-3 polyunsaturated fatty acids (PUFAs) is closely related to depression and cognitive impairment in middle and later life. This study investigated the preventive effects of n-3 PUFA-rich oils on the behavioural impairment of unchallenged aged prediabetic rats by using a Morris water maze (MWM) test and forced swimming test (FST). Twenty 102-wk-old male SD male rats received a 35% sucrose solution and were fed with fish oil or flaxseed oil diets for 8k. Both treatments reduced the production of IL-6 and non-esterified fatty acids significantly. Both treatments demonstrated significantly quicker MWM acquisition, shorter FST immobility time and higher levels of nerve growth factor than did the control group. Thus, n-3 PUFA-rich oil might produce protective effects by improving fasting blood sugar levels and reducing proinflammatory cytokine levels, thus preventing cognitive age-related impairments and depression-like behaviour in aged prediabetic rats.

Original languageEnglish
Article number1300
Pages (from-to)522-536
Number of pages15
JournalJournal of Functional Foods
Volume19
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Cognitive impairment
  • Depression
  • Fatty acid

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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