Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats

I. M. Liu, Shorong Shii Liou, Ting W. Lan, Feng L. Hsu, Juei Tang Cheng

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

The antihyperglycemic action of myricetin, purified from the aerial part of Abelmoschus moschatus (Malvaceae), was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection of myricetin decreased the plasma glucose concentrations in a dose-dependent manner in STZ-diabetic rats. Myricetin at the effective dose (1.0 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A stimulatory effect of myricetin on glucose uptake of the soleus muscles isolated from STZ-diabetic rats was obtained in a concentration-dependent manner from 0.01 to 10.0 μmol/L. The increase of glucose utilization by myricetin was further characterized using the enhancement of glycogen synthesis in isolated hepatocytes of STZ-diabetic rats. These results suggest that myricetin has an ability to enhance glucose utilization to lower plasma glucose in diabetic rats lacking insulin.

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalPlanta Medica
Volume71
Issue number7
DOIs
Publication statusPublished - Jul 2005

Keywords

  • Abelmoschus moschatus
  • Glucose uptake
  • Glycogen synthesis
  • Malvaceae
  • Myricetin
  • STZ-diabetic rats

ASJC Scopus subject areas

  • Plant Science
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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