Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

Chia Wei Sun, Yih Ming Wang, Long Sheng Lu, Chih Wei Lu, I. Jen Hsu, Meng Tsan Tsai, C. C. Yang, Yean Woei Kiang, Chau Chung Wu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.

Original languageEnglish
Article number054016
JournalJournal of Biomedical Optics
Volume11
Issue number5
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

Fingerprint

ultrashort pulsed lasers
Optical tomography
Optical Coherence Tomography
Pulsed lasers
Lasers
tomography
Polarization
Tissue
polarization
Birefringence
Myocardium
muscle fibers
Light
myocardium
Muscles
Ultrashort pulses
rats
destruction
birefringence
Light sources

Keywords

  • Lasers
  • Medical imaging
  • Microscopy
  • Optical systems
  • Polarization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry

Cite this

Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser. / Sun, Chia Wei; Wang, Yih Ming; Lu, Long Sheng; Lu, Chih Wei; Hsu, I. Jen; Tsai, Meng Tsan; Yang, C. C.; Kiang, Yean Woei; Wu, Chau Chung.

In: Journal of Biomedical Optics, Vol. 11, No. 5, 054016, 09.2006.

Research output: Contribution to journalArticle

Sun, Chia Wei ; Wang, Yih Ming ; Lu, Long Sheng ; Lu, Chih Wei ; Hsu, I. Jen ; Tsai, Meng Tsan ; Yang, C. C. ; Kiang, Yean Woei ; Wu, Chau Chung. / Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser. In: Journal of Biomedical Optics. 2006 ; Vol. 11, No. 5.
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