Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

Chia Wei Sun, Yih Ming Wang, Long Sheng Lu, Chih Wei Lu, I. Jen Hsu, Meng Tsan Tsai, C. C. Yang, Yean Woei Kiang, Chau Chung Wu

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.

Original languageEnglish
Article number054016
JournalJournal of Biomedical Optics
Volume11
Issue number5
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

Keywords

  • Lasers
  • Medical imaging
  • Microscopy
  • Optical systems
  • Polarization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry

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