Myeloproliferative syndromes: A unique presentation of chronic myelogenous leukemia (CML) as a primary tumor of bone

D. L. Longo, J. Whang-Peng, E. Jaffe, T. J. Triche, R. C. Young

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11 Citations (Scopus)


A 45-yr-old female presented with a rapidly enlarging bony tumor that was eventually identified as a Philadelphia chromosome (Ph1)-positive myeloproliferative disorder with extramedullary blastic transformation. This transformation occurred in the absence of demonstrable chronic or acute leukemic phase. She had no history of a chronic or prodromal illness in spite of a bone marrow biopsy showing myelofibrosis and liver biopsy documenting extramedullary hematopoiesis. This case represents a unique constellation of features of the myeloproliferative syndrome in which the diagnosis was obscure until special stains of the bony tumor and cytogenetic studies were performed.

Original languageEnglish
Pages (from-to)793-801
Number of pages9
Issue number4
Publication statusPublished - Dec 1 1978
Externally publishedYes


ASJC Scopus subject areas

  • Hematology

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