Myeloproliferative syndromes

A unique presentation of chronic myelogenous leukemia (CML) as a primary tumor of bone

D. L. Longo, J. Whang-Peng, E. Jaffe, T. J. Triche, R. C. Young

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 45-yr-old female presented with a rapidly enlarging bony tumor that was eventually identified as a Philadelphia chromosome (Ph1)-positive myeloproliferative disorder with extramedullary blastic transformation. This transformation occurred in the absence of demonstrable chronic or acute leukemic phase. She had no history of a chronic or prodromal illness in spite of a bone marrow biopsy showing myelofibrosis and liver biopsy documenting extramedullary hematopoiesis. This case represents a unique constellation of features of the myeloproliferative syndrome in which the diagnosis was obscure until special stains of the bony tumor and cytogenetic studies were performed.

Original languageEnglish
Pages (from-to)793-801
Number of pages9
JournalBlood
Volume52
Issue number4
Publication statusPublished - Dec 1 1978
Externally publishedYes

Fingerprint

Biopsy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tumors
Bone
Extramedullary Hematopoiesis
Bone and Bones
Philadelphia Chromosome
Myeloproliferative Disorders
Primary Myelofibrosis
Chromosomes
Cytogenetics
Liver
Neoplasms
Coloring Agents
Bone Marrow

ASJC Scopus subject areas

  • Hematology

Cite this

Myeloproliferative syndromes : A unique presentation of chronic myelogenous leukemia (CML) as a primary tumor of bone. / Longo, D. L.; Whang-Peng, J.; Jaffe, E.; Triche, T. J.; Young, R. C.

In: Blood, Vol. 52, No. 4, 01.12.1978, p. 793-801.

Research output: Contribution to journalArticle

Longo, D. L. ; Whang-Peng, J. ; Jaffe, E. ; Triche, T. J. ; Young, R. C. / Myeloproliferative syndromes : A unique presentation of chronic myelogenous leukemia (CML) as a primary tumor of bone. In: Blood. 1978 ; Vol. 52, No. 4. pp. 793-801.
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