Mycobacterium tuberculosis infection of end-stage renal disease patients in Taiwan: A nationwide longitudinal study

S. Y. Li, T. J. Chen, K. W. Chung, L. W. Tsai, W. C. Yang, J. Y. Chen, T. W. Chen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

End-stage renal disease (ESRD) patients are vulnerable to Mycobacterium tuberculosis (MTB) infection, but the magnitude of the risk is uncertain. In addition, there is no reliable information on the MTB infection rate of patients undergoing different types of renal replacement therapy (RRT). We used the Taiwan National Health Insurance Research Database to conduct a 9-year nationwide longitudinal study. Among 49983 ESRD patients who received three renal replacement modalities, there were 562 cases of MTB infection, corresponding to an incidence rate of 3.0 per 1000 patient-years. The risk of MTB infection relative to the general population was 4.5. Multivariate Cox regression analysis indicated that the independent risk factors for MTB infection in ESRD patients are old age (hazard ratio (HR) 1.17 per 10 years, p

Original languageEnglish
Pages (from-to)1646-1652
Number of pages7
JournalClinical Microbiology and Infection
Volume17
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • End-stage renal disease
  • Mycobacterium tuberculosis
  • Renal replacement therapy
  • Taiwan National Health Insurance Research Database

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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