Mutations of p53 gene in hepatocellular carcinoma (HCC) correlate with tumor progression and patient prognosis: A study of 138 patients with unifocal HCC

H. C. Hsu, S. Y. Peng, P. L. Lai, J. S. Chu, P. H. Lee

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The mutation spectrum of p53 gene and its biological significance were studied in 138 patients with unifocal primary hepatocellular carcinoma (HCC) in Taiwan. The p53 mutations were detected in 51 cases (37%); 36 (71%) were missense mutations. The others (29%) included mutations at the intron-exon junctions (5 cases), deletion or insertion (4 cases), nonsense mutations (4 cases), and silent mutations (2 cases). The mutation sites were scattered from exons 4 to 10, predominantly (75%) in exons 5, 7, and 8. Of these mutations, 72% were transversions, mostly G:C→T:A change (46%); while only 28% were transitions. Mutation occurred at codon 249 only in 14 cases (10%), but accounted for 27% of the mutations. The p53 mutations correlated with allele loss of p53 locus (52% vs 17%, p

Original languageEnglish
Pages (from-to)1341-1347
Number of pages7
JournalInternational Journal of Oncology
Volume4
Issue number6
Publication statusPublished - 1994
Externally publishedYes

Keywords

  • hepatocellular carcinoma
  • p53 gene mutation
  • prognosis
  • tumor progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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