Mutant Lines of Guinea Pig L2C Leukemia. II. Comparative Cytogenetic Studies and Banding Analyses of Normal and Leukemic Karyotypes

J. Whang Peng, E. C. Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Chromosomes of normal guinea pig (strain 2) cells and of cell lines derived from a spontaneously arising leukemia were analyzed in detail. All cell lines studied, LG-L2C, GH-L2C, BZ-L*C, and EN-L2C, contained one M1 marker and two X chromosomes, in addition to other chromosome abnormalities specific for each cell line. The presence of the M1 marker and the two X chromosomes confirmed that all of these leukemic cell lines are derived from one ancestral line. Comparison of the chromosome markers and immunologic characteristics of these lines revealed that possibly the gene involved in the determination of C3receptor sites is located on the terminal portion of the long arm of chromosome #2, but no other correlations could be made.

Original languageEnglish
Pages (from-to)897-905
Number of pages9
JournalJournal of the National Cancer Institute
Volume57
Issue number4
DOIs
Publication statusPublished - Jan 1 1976
Externally publishedYes

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Karyotype
Cytogenetics
Guinea Pigs
Leukemia
Cell Line
X Chromosome
Chromosomes, Human, Pair 2
Genetic Markers
Chromosome Aberrations
Chromosomes
Genes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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