Mutagenicity study of butachlor and its metabolites using Salmonella typhimurium

Kuei Yao Hsu, Hwai Jeng Lin, Jen Kun Lin, Wein Shung Kuo, Yueh Hsing Ou

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Butachlor is the most commonly used herbicide in Taiwan and many other countries. It has been reported to be an indirect mutagen and carcinogen in various in vitro assay systems. Previous investigation has also demonstrated that butachlor stimulates cell proliferation, transforms normal embryonic cells, and induces stomach tumors in Spraque-Dawley rats. However, the mechanism of butachlor carcinogenicity is still not clear. In order to clarify the toxicologic and carcinogenic properties of butachlor, we proposed a metabolic pathway, and synthesized the authentic metabolites by chemical methods. In addition, we tested the mutagenicity of butachlor and these metabolites on Salmonella typhimurium. The results indicate that butachlor might manifest its carcinogenicity via the mutagenicity of its metabolic products. Although the molecular mechanism of butachlor-induced cellular toxicity is still not clear, it is likely that the cellular transformation ability of butachlor is partly associated with its mutagenicity.

Original languageEnglish
Pages (from-to)409-416
Number of pages8
JournalJournal of Microbiology, Immunology and Infection
Volume38
Issue number6
Publication statusPublished - Dec 2005
Externally publishedYes

Keywords

  • Acetamides
  • Acetanilides
  • Butachlor
  • Mutagenicity tests
  • Salmonella typhimurium

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

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