Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas

Tang Her Jaing, Huei Shyong Wang, Pei Kwei Tsay, Chen Kan Tseng, Shih Ming Jung, Kuang Lin Lin, Tai Ngar Lui

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were anaplastic. Complete resection was performed in 18 patients, incomplete resection in 19, and stereotactic biopsy in 6. Radiotherapy was done in 31 patients and chemotherapy in 13. The surviving patients have been followed 8-232 months (median: 69 months). The median survival time was 30 months, and 5-year overall survival and progression-free survival rates were 53.9% and 45.9%, respectively. By tumor site: supratentorial, 56.6% and 50.9%; infratentorial, 52.3% and 42.5%. Multivariate analysis identified complete resection (5-year progression-free survival, 71.8%) and age

Original languageEnglish
Pages (from-to)255-261
Number of pages7
JournalJournal of Neuro-Oncology
Volume68
Issue number3
DOIs
Publication statusPublished - Jul 2004
Externally publishedYes

    Fingerprint

Keywords

  • Chemotherapy
  • Children
  • Intracranial ependymoma
  • Radiotherapy
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

Cite this

Jaing, T. H., Wang, H. S., Tsay, P. K., Tseng, C. K., Jung, S. M., Lin, K. L., & Lui, T. N. (2004). Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas. Journal of Neuro-Oncology, 68(3), 255-261. https://doi.org/10.1023/B:NEON.0000033383.84900.c1