Abstract

Sleep disorders are frequently seen in patients with Parkinson disease (PD), including rapid eye movement (REM) behavior disorder and periodic limb movement disorder. However, knowledge about changes in non-REM sleep in patients with PD is limited. This study explored the characteristics of electroencephalography (EEG) during sleep in patients with PD and non-PD controls. We further conducted multiscale entropy (MSE) analysis to evaluate and compare the complexity of sleep EEG for the 2 groups. There were 9 patients with PD (Hoehn-Yahr stage 1 or 2) and 11 non-PD controls. All participants underwent standard whole-night polysomnography (PSG), which included 23 channels, 6 of which were for EEG. The raw data of the EEG were extracted and subjected to MSE analysis. Patients with PD had a longer sleep onset time and a higher spontaneous EEG arousal index. Sleep stage-specific increased MSE was observed in patients with PD during non-REM sleep. The difference was more marked and significant at higher time scale factors (TSFs). In conclusion, increased biosignal complexity, as revealed by MSE analysis, was found in patients with PD during non-REM sleep at high TSFs. This finding might reflect a compensatory mechanism for early defects in neuronal network control machinery in PD.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalClinical EEG and Neuroscience
Volume44
Issue number3
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Entropy
Parkinson Disease
Electroencephalography
Sleep
Eye Movements
Nocturnal Myoclonus Syndrome
Ocular Motility Disorders
Polysomnography
Sleep Stages
REM Sleep
Arousal
Mental Disorders

Keywords

  • Electroencephalography
  • Entropy
  • Parkinson disease
  • Polysomnography
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

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abstract = "Sleep disorders are frequently seen in patients with Parkinson disease (PD), including rapid eye movement (REM) behavior disorder and periodic limb movement disorder. However, knowledge about changes in non-REM sleep in patients with PD is limited. This study explored the characteristics of electroencephalography (EEG) during sleep in patients with PD and non-PD controls. We further conducted multiscale entropy (MSE) analysis to evaluate and compare the complexity of sleep EEG for the 2 groups. There were 9 patients with PD (Hoehn-Yahr stage 1 or 2) and 11 non-PD controls. All participants underwent standard whole-night polysomnography (PSG), which included 23 channels, 6 of which were for EEG. The raw data of the EEG were extracted and subjected to MSE analysis. Patients with PD had a longer sleep onset time and a higher spontaneous EEG arousal index. Sleep stage-specific increased MSE was observed in patients with PD during non-REM sleep. The difference was more marked and significant at higher time scale factors (TSFs). In conclusion, increased biosignal complexity, as revealed by MSE analysis, was found in patients with PD during non-REM sleep at high TSFs. This finding might reflect a compensatory mechanism for early defects in neuronal network control machinery in PD.",
keywords = "Electroencephalography, Entropy, Parkinson disease, Polysomnography, Sleep",
author = "Chih-Chung Chen and Kang, {Jiunn Horng} and Yuan, {Rey Yue} and Dean Wu and Chen, {Chih Chung} and Chi, {Nai Fang} and Chen, {Po Chih} and Hu, {Chaur Jong}",
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