Multiple subependymal pseudocysts in neonates play a role in later attention deficit hyperactivity and autistic spectrum disorder

Hsi Chang, Chung Min Tsai, Chun Yin Hou, Sung Hui Tseng, Ju Chin Lee, Min Lan Tsai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/purpose: To assess the long-term neurodevelopmental outcome of normal-term neonates who were accidentally found to exhibit subependymal pseudocysts (SEPCs), frontal horn cysts, or choroid plexus cysts through cranial ultrasound (CUS) examination in a neonatal health examination. Methods: In total, 5569 neonates received CUS examination as an item in a health examination during the first week of birth between 2002 and 2012. Among them, 5147 infants fulfilled the inclusion criteria. The participants were aged between 5 and 15 years at the time when the data were collected. We retrospectively collected these data and interpreted their statistical significance by using one-way analysis of variance, Chi-square test with Yate's correction and odds ratios. Results: The presence of SEPCs was significantly correlated with developmental delay and developmental disability, particularly with attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). The risk of ADHD or ASD was significantly higher in participants with multiple SEPCs, among whom the odds ratios for ADHD and ASD were 6.50 (95% confidence interval [CI] = 2.27–18.64) and 28.54 (95% CI = 5.98–136.36), respectively, higher than those for the total study population. Conclusions: Our data revealed multiple SEPCs in normal-term neonates as a risk factor for neurobehavioral outcome, particularly in ADHD and ASD. Simultaneously, the utility of CUS examination as a health examination item for neonates was confirmed.

Original languageEnglish
JournalJournal of the Formosan Medical Association
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Attention Deficit Disorder with Hyperactivity
Autistic Disorder
Newborn Infant
Cysts
Odds Ratio
Confidence Intervals
Developmental Disabilities
Birth Order
Choroid Plexus
Health
Chi-Square Distribution
Horns
Analysis of Variance
Population

Keywords

  • Attention deficit hyperactivity disorder
  • Autistic spectrum disorder
  • Multiple subependymal pseudocysts
  • Normal-full term neonates

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{12d37e04586b4530b4fa13f8b25a036d,
title = "Multiple subependymal pseudocysts in neonates play a role in later attention deficit hyperactivity and autistic spectrum disorder",
abstract = "Background/purpose: To assess the long-term neurodevelopmental outcome of normal-term neonates who were accidentally found to exhibit subependymal pseudocysts (SEPCs), frontal horn cysts, or choroid plexus cysts through cranial ultrasound (CUS) examination in a neonatal health examination. Methods: In total, 5569 neonates received CUS examination as an item in a health examination during the first week of birth between 2002 and 2012. Among them, 5147 infants fulfilled the inclusion criteria. The participants were aged between 5 and 15 years at the time when the data were collected. We retrospectively collected these data and interpreted their statistical significance by using one-way analysis of variance, Chi-square test with Yate's correction and odds ratios. Results: The presence of SEPCs was significantly correlated with developmental delay and developmental disability, particularly with attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). The risk of ADHD or ASD was significantly higher in participants with multiple SEPCs, among whom the odds ratios for ADHD and ASD were 6.50 (95{\%} confidence interval [CI] = 2.27–18.64) and 28.54 (95{\%} CI = 5.98–136.36), respectively, higher than those for the total study population. Conclusions: Our data revealed multiple SEPCs in normal-term neonates as a risk factor for neurobehavioral outcome, particularly in ADHD and ASD. Simultaneously, the utility of CUS examination as a health examination item for neonates was confirmed.",
keywords = "Attention deficit hyperactivity disorder, Autistic spectrum disorder, Multiple subependymal pseudocysts, Normal-full term neonates",
author = "Hsi Chang and Tsai, {Chung Min} and Hou, {Chun Yin} and Tseng, {Sung Hui} and Lee, {Ju Chin} and Tsai, {Min Lan}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.jfma.2018.08.007",
language = "English",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",

}

TY - JOUR

T1 - Multiple subependymal pseudocysts in neonates play a role in later attention deficit hyperactivity and autistic spectrum disorder

AU - Chang, Hsi

AU - Tsai, Chung Min

AU - Hou, Chun Yin

AU - Tseng, Sung Hui

AU - Lee, Ju Chin

AU - Tsai, Min Lan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background/purpose: To assess the long-term neurodevelopmental outcome of normal-term neonates who were accidentally found to exhibit subependymal pseudocysts (SEPCs), frontal horn cysts, or choroid plexus cysts through cranial ultrasound (CUS) examination in a neonatal health examination. Methods: In total, 5569 neonates received CUS examination as an item in a health examination during the first week of birth between 2002 and 2012. Among them, 5147 infants fulfilled the inclusion criteria. The participants were aged between 5 and 15 years at the time when the data were collected. We retrospectively collected these data and interpreted their statistical significance by using one-way analysis of variance, Chi-square test with Yate's correction and odds ratios. Results: The presence of SEPCs was significantly correlated with developmental delay and developmental disability, particularly with attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). The risk of ADHD or ASD was significantly higher in participants with multiple SEPCs, among whom the odds ratios for ADHD and ASD were 6.50 (95% confidence interval [CI] = 2.27–18.64) and 28.54 (95% CI = 5.98–136.36), respectively, higher than those for the total study population. Conclusions: Our data revealed multiple SEPCs in normal-term neonates as a risk factor for neurobehavioral outcome, particularly in ADHD and ASD. Simultaneously, the utility of CUS examination as a health examination item for neonates was confirmed.

AB - Background/purpose: To assess the long-term neurodevelopmental outcome of normal-term neonates who were accidentally found to exhibit subependymal pseudocysts (SEPCs), frontal horn cysts, or choroid plexus cysts through cranial ultrasound (CUS) examination in a neonatal health examination. Methods: In total, 5569 neonates received CUS examination as an item in a health examination during the first week of birth between 2002 and 2012. Among them, 5147 infants fulfilled the inclusion criteria. The participants were aged between 5 and 15 years at the time when the data were collected. We retrospectively collected these data and interpreted their statistical significance by using one-way analysis of variance, Chi-square test with Yate's correction and odds ratios. Results: The presence of SEPCs was significantly correlated with developmental delay and developmental disability, particularly with attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). The risk of ADHD or ASD was significantly higher in participants with multiple SEPCs, among whom the odds ratios for ADHD and ASD were 6.50 (95% confidence interval [CI] = 2.27–18.64) and 28.54 (95% CI = 5.98–136.36), respectively, higher than those for the total study population. Conclusions: Our data revealed multiple SEPCs in normal-term neonates as a risk factor for neurobehavioral outcome, particularly in ADHD and ASD. Simultaneously, the utility of CUS examination as a health examination item for neonates was confirmed.

KW - Attention deficit hyperactivity disorder

KW - Autistic spectrum disorder

KW - Multiple subependymal pseudocysts

KW - Normal-full term neonates

UR - http://www.scopus.com/inward/record.url?scp=85052869897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052869897&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2018.08.007

DO - 10.1016/j.jfma.2018.08.007

M3 - Article

AN - SCOPUS:85052869897

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

ER -