Multiple roles of RBM4 in muscle cell differentiation

Jung Chun Lin, Woan Yuh Tarn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Muscle cell differentiation involves gene regulation at both transcriptional and post-transcriptional steps. Post-transcriptional control requires various RNA binding proteins. The multi-functional RNA binding motif 4 (RBM4) protein participates in both precursor mRNA splicing regulation and translational control in muscle cells. In myoblasts, RBM4 promotes the expression of many muscle-specific mRNAs from individual genes via its activity in modulating alternative splicing. In addition, RBM4 transiently translocates to the cytoplasm during myogenesis, where it participates in translation control. RBM4 may act in conjunction with a subset of musclespecific microRNAs to modulate their activity in translation suppression. Overexpression of RBM4 promotes muscle cell differentiation, suggesting that RBM4 acts as a positive myogenic regulator. In this review, we discuss recent data regarding how RBM4 may foster muscle cell differentiation.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalFrontiers in Bioscience - Scholar
Volume4 S
Issue number1
Publication statusPublished - Jan 1 2012
Externally publishedYes

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Keywords

  • Alternative splicing
  • Myogenesis
  • Nonsense-mediated RNA decay
  • RNA binding proteins
  • Translation

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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