Multiparametric analysis of cerebral substrates and nitric oxide delivery in cerebrospinal fluid in patients with intracerebral haemorrhage: Correlation with hemodynamics and outcome

Ming Fu Chiang, Wen Ta Chiu, Fung J. Lin, Peterus Thajeb, Chun Jen Huang, Shin Han Tsai

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background. There is no information regarding the possible role of cerebral substrates in the pathogenesis of neuronal injury in intracerebral haemorrhages (ICHs). Purposes of this prospective study were to clarify whether changes in substrates are the consequence of the initial brain damage in ICH and to elucidate the relationship among the biochemical mechanisms and clinical course of patients with ICH. Method. During a period of two years, patients (GCS ≤8) who had ICH secondary to an aneurysm (SAH), stroke (sICH), or trauma (tICH) and underwent ventriculostomy with ICP monitoring and/or underwent cranial surgery were randomly enrolled in this study. Extracellular concentrations of glutamate, aspartate, glycine, GABA, lactate, lactate/pyruvate ratio, and glucose in the CSF were measured by use of high-performance liquid chromatography (HPLC). The nitric oxide (NO) concentration in the CSF was analyzed by chemiluminescence. Findings. There were 75 patients (38 women and 37 men) with ICH included in this study. Twenty-one patients had SAH, 28 sICH, and 26 tICH. In tICH patients, there was a 30-fold increase in glutamate and a 10-fold in aspartate over reference values. The levels of glutamate, aspirate, GABA, lactate, glucose, and NO differed significantly among the three groups (p

Original languageEnglish
Pages (from-to)615-621
Number of pages7
JournalActa Neurochirurgica
Volume148
Issue number6
DOIs
Publication statusPublished - Jun 2006

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Cerebral Hemorrhage
Cerebrospinal Fluid
Nitric Oxide
Hemodynamics
Glutamic Acid
Lactic Acid
Aspartic Acid
gamma-Aminobutyric Acid
Ventriculostomy
Glucose
Wounds and Injuries
Luminescence
Pyruvic Acid
Glycine
Aneurysm
Reference Values
Stroke
High Pressure Liquid Chromatography
Prospective Studies
Brain

Keywords

  • Cerebral substrates
  • Excitatory amino acid (EAA)
  • Intracerebral haemorrhage (ICH)
  • Microdialysis
  • Nitric oxide (NO)
  • Subarachnoid haemorrhage (SAH)

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Multiparametric analysis of cerebral substrates and nitric oxide delivery in cerebrospinal fluid in patients with intracerebral haemorrhage : Correlation with hemodynamics and outcome. / Chiang, Ming Fu; Chiu, Wen Ta; Lin, Fung J.; Thajeb, Peterus; Huang, Chun Jen; Tsai, Shin Han.

In: Acta Neurochirurgica, Vol. 148, No. 6, 06.2006, p. 615-621.

Research output: Contribution to journalArticle

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