Multifunctions of Excited Gold Nanoparticles Decorated Artificial Kidney with Efficient Hemodialysis and Therapeutic Potential

Hsiao Chien Chen, Chung Yi Cheng, Hsiu Chen Lin, Hsi Hsien Chen, Cheng Hsien Chen, Chih Ping Yang, Kai Huei Yang, Chun Mao Lin, Tsung Yao Lin, Chwen Ming Shih, Yu Chuan Liu

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Abstract

Chronic kidney disease (CKD) is inflammation-related. Patients with chronic renal failure who undergo hemodialysis (HD) have some acute adverse effects caused by dialysis-induced oxidative stress, protein adsorption, platelet adhesion, and activation of coagulation and inflammation. Here, resonantly illuminated gold nanoparticles-modified artificial kidney (AuNPs@AK) for achieving high efficiency accompanying therapeutic strategy for CKD during HD is proposed. The efficiency in removing uremic toxins increased obviously, especially in the presence of protein (closer to the real blood). The excited AuNPs@AK expressed negatively charged surface reduced some acute adverse effects caused by dialysis-induced protein adsorption, platelet adhesion, and activation of coagulation, thus avoiding thrombosis during HD. Unlike to traditional HD which provides only one function of removing uremic toxins, the solution collected from the outlet of the sample channel of excited AuNPs@AK showed an efficient free radical scavenger that could decrease dialysis-induced oxidative stress. In the CKD mouse model, this antioxidative solution from excited AuNPs@AK further decreased fibronectin expression and attenuated renal fibrosis, suggesting a reduced inflammatory response. These successful in vitro and in vivo approaches suggest that resonantly illuminated AuNPs@AK in HD take multiadvantages in shortening treatment time and reducing risk of adverse effects, which promise trailblazing therapeutic strategies for CKD.

Original languageEnglish
Pages (from-to)19691-19700
Number of pages10
JournalACS Applied Materials and Interfaces
Volume8
Issue number30
DOIs
Publication statusPublished - Aug 3 2016

Fingerprint

Gold
Dialysis
Nanoparticles
Oxidative stress
Platelets
Coagulation
Proteins
Adhesion
Chemical activation
Adsorption
Free Radical Scavengers
Heat-Shock Proteins
Free radicals
Fibronectins
Blood

Keywords

  • artificial kidney
  • chronic kidney disease
  • gold nanoparticle
  • hemodialysis
  • multifunctions

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

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title = "Multifunctions of Excited Gold Nanoparticles Decorated Artificial Kidney with Efficient Hemodialysis and Therapeutic Potential",
abstract = "Chronic kidney disease (CKD) is inflammation-related. Patients with chronic renal failure who undergo hemodialysis (HD) have some acute adverse effects caused by dialysis-induced oxidative stress, protein adsorption, platelet adhesion, and activation of coagulation and inflammation. Here, resonantly illuminated gold nanoparticles-modified artificial kidney (AuNPs@AK) for achieving high efficiency accompanying therapeutic strategy for CKD during HD is proposed. The efficiency in removing uremic toxins increased obviously, especially in the presence of protein (closer to the real blood). The excited AuNPs@AK expressed negatively charged surface reduced some acute adverse effects caused by dialysis-induced protein adsorption, platelet adhesion, and activation of coagulation, thus avoiding thrombosis during HD. Unlike to traditional HD which provides only one function of removing uremic toxins, the solution collected from the outlet of the sample channel of excited AuNPs@AK showed an efficient free radical scavenger that could decrease dialysis-induced oxidative stress. In the CKD mouse model, this antioxidative solution from excited AuNPs@AK further decreased fibronectin expression and attenuated renal fibrosis, suggesting a reduced inflammatory response. These successful in vitro and in vivo approaches suggest that resonantly illuminated AuNPs@AK in HD take multiadvantages in shortening treatment time and reducing risk of adverse effects, which promise trailblazing therapeutic strategies for CKD.",
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author = "Chen, {Hsiao Chien} and Cheng, {Chung Yi} and Lin, {Hsiu Chen} and Chen, {Hsi Hsien} and Chen, {Cheng Hsien} and Yang, {Chih Ping} and Yang, {Kai Huei} and Lin, {Chun Mao} and Lin, {Tsung Yao} and Shih, {Chwen Ming} and Liu, {Yu Chuan}",
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AU - Chen, Hsiao Chien

AU - Cheng, Chung Yi

AU - Lin, Hsiu Chen

AU - Chen, Hsi Hsien

AU - Chen, Cheng Hsien

AU - Yang, Chih Ping

AU - Yang, Kai Huei

AU - Lin, Chun Mao

AU - Lin, Tsung Yao

AU - Shih, Chwen Ming

AU - Liu, Yu Chuan

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N2 - Chronic kidney disease (CKD) is inflammation-related. Patients with chronic renal failure who undergo hemodialysis (HD) have some acute adverse effects caused by dialysis-induced oxidative stress, protein adsorption, platelet adhesion, and activation of coagulation and inflammation. Here, resonantly illuminated gold nanoparticles-modified artificial kidney (AuNPs@AK) for achieving high efficiency accompanying therapeutic strategy for CKD during HD is proposed. The efficiency in removing uremic toxins increased obviously, especially in the presence of protein (closer to the real blood). The excited AuNPs@AK expressed negatively charged surface reduced some acute adverse effects caused by dialysis-induced protein adsorption, platelet adhesion, and activation of coagulation, thus avoiding thrombosis during HD. Unlike to traditional HD which provides only one function of removing uremic toxins, the solution collected from the outlet of the sample channel of excited AuNPs@AK showed an efficient free radical scavenger that could decrease dialysis-induced oxidative stress. In the CKD mouse model, this antioxidative solution from excited AuNPs@AK further decreased fibronectin expression and attenuated renal fibrosis, suggesting a reduced inflammatory response. These successful in vitro and in vivo approaches suggest that resonantly illuminated AuNPs@AK in HD take multiadvantages in shortening treatment time and reducing risk of adverse effects, which promise trailblazing therapeutic strategies for CKD.

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