Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method

Carole D. Mitnick, Richard A. White, Chunling Lu, Carly A. Rodriguez, Jaime Bayona, Mercedes C. Becerra, Marcos Burgos, Rosella Centis, Theodore Cohen, Helen Cox, Lia D'Ambrosio, Manfred Danilovitz, Dennis Falzon, Irina Y. Gelmanova, Maria T. Gler, Jennifer A. Grinsdale, Timothy H. Holtz, Salmaan Keshavjee, Vaira Leimane, Dick MenziesGiovanni Battista Migliori, Meredith B. Milstein, Sergey P. Mishustin, Marcello Pagano, Maria I. Quelapio, Karen Shean, Sonya S. Shin, Arielle W. Tolman, Martha L. Van Der Walt, Armand Van Deun, Piret Viiklepp, Shama D. Ahuja, Yevgeny G. Andreev, David Ashkin, Monika Avendano, Rita Banerjee, Melissa Bauer, Andrea Benedetti, Jeannette Brand, Edward D. Chan, Chen Yuan Chiang, Kathy DeRiemer, Nguyen Huy Dung, Donald Enarson, Katherine Flanagan, Jennifer Flood, Maria L. Garcia-Garcia, Neel Gandhi, Reuben M. Granich, Maria G. Hollm-Delgado, Michael D. Iseman, Leah G. Jarlsberg, Hye Ryoun Kim, Won Jung Koh, Joey Lancaster, Christophe Lange, Wiel C M De Lange, Chi Chiu Leung, Jiehui Li, Aung Kya Jai Maug, Masa Narita, Ronel Odendaal, Philly O'Riordan, Madhukar Pai, Domingo Palmero, Seung-Kyu, Geoffrey Pasvol, Jose Peña, Carlos Pérez-Guzmán, Alfredo Ponce-De-Leon, Vija Riekstina, Jerome Robert, Sarah Royce, H. Simon Schaaf, Kwonjune J. Seung, Lena Shah, Tae Sun Shim, Yuji Shiraishi, José Sifuentes-Osornio, Matthew J. Strand, Payam Tabarsi Shaheed, Thelma E. Tupasi, Robert Van Altena, Tjip S. Van Der Werf, Mario H. Vargas, Janice Westenhouse, Wing Wai Yew, Jae Joon Yim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of monitoring strategies on timing of failure detection. We identified studies reporting microbiological response to MDR-TB treatment and solicited individual patient data from authors. Frailty survival models were used to estimate pooled relative risk of failure detection in the last 12 months of treatment; hazard of failure using monthly culture was the reference. Data were obtained for 5410 patients across 12 observational studies. During the last 12 months of treatment, failure detection occurred in a median of 3 months by monthly culture; failure detection was delayed by 2, 7, and 9 months relying on bimonthly culture, monthly smear and bimonthly smear, respectively. Risk (95% CI) of failure detection delay resulting from monthly smear relative to culture is 0.38 (0.34-0.42) for all patients and 0.33 (0.25-0.42) for HIV-co-infected patients. Failure detection is delayed by reducing the sensitivity and frequency of the monitoring method. Monthly monitoring of sputum cultures from patients receiving MDR-TB treatment is recommended. Expanded laboratory capacity is needed for high-quality culture, and for smear microscopy and rapid molecular tests.

Original languageEnglish
Pages (from-to)1160-1170
Number of pages11
JournalEuropean Respiratory Journal
Volume48
Issue number4
DOIs
Publication statusPublished - Oct 1 2016
Externally publishedYes

Fingerprint

Multidrug-Resistant Tuberculosis
Treatment Failure
Therapeutics
Sputum
Observational Studies
Microscopy
HIV
Survival

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Mitnick, C. D., White, R. A., Lu, C., Rodriguez, C. A., Bayona, J., Becerra, M. C., ... Yim, J. J. (2016). Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method. European Respiratory Journal, 48(4), 1160-1170. https://doi.org/10.1183/13993003.00462-2016

Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method. / Mitnick, Carole D.; White, Richard A.; Lu, Chunling; Rodriguez, Carly A.; Bayona, Jaime; Becerra, Mercedes C.; Burgos, Marcos; Centis, Rosella; Cohen, Theodore; Cox, Helen; D'Ambrosio, Lia; Danilovitz, Manfred; Falzon, Dennis; Gelmanova, Irina Y.; Gler, Maria T.; Grinsdale, Jennifer A.; Holtz, Timothy H.; Keshavjee, Salmaan; Leimane, Vaira; Menzies, Dick; Migliori, Giovanni Battista; Milstein, Meredith B.; Mishustin, Sergey P.; Pagano, Marcello; Quelapio, Maria I.; Shean, Karen; Shin, Sonya S.; Tolman, Arielle W.; Van Der Walt, Martha L.; Van Deun, Armand; Viiklepp, Piret; Ahuja, Shama D.; Andreev, Yevgeny G.; Ashkin, David; Avendano, Monika; Banerjee, Rita; Bauer, Melissa; Benedetti, Andrea; Brand, Jeannette; Chan, Edward D.; Chiang, Chen Yuan; DeRiemer, Kathy; Dung, Nguyen Huy; Enarson, Donald; Flanagan, Katherine; Flood, Jennifer; Garcia-Garcia, Maria L.; Gandhi, Neel; Granich, Reuben M.; Hollm-Delgado, Maria G.; Iseman, Michael D.; Jarlsberg, Leah G.; Kim, Hye Ryoun; Koh, Won Jung; Lancaster, Joey; Lange, Christophe; De Lange, Wiel C M; Leung, Chi Chiu; Li, Jiehui; Maug, Aung Kya Jai; Narita, Masa; Odendaal, Ronel; O'Riordan, Philly; Pai, Madhukar; Palmero, Domingo; Seung-Kyu; Pasvol, Geoffrey; Peña, Jose; Pérez-Guzmán, Carlos; Ponce-De-Leon, Alfredo; Riekstina, Vija; Robert, Jerome; Royce, Sarah; Schaaf, H. Simon; Seung, Kwonjune J.; Shah, Lena; Shim, Tae Sun; Shiraishi, Yuji; Sifuentes-Osornio, José; Strand, Matthew J.; Shaheed, Payam Tabarsi; Tupasi, Thelma E.; Van Altena, Robert; Van Der Werf, Tjip S.; Vargas, Mario H.; Westenhouse, Janice; Yew, Wing Wai; Yim, Jae Joon.

In: European Respiratory Journal, Vol. 48, No. 4, 01.10.2016, p. 1160-1170.

Research output: Contribution to journalArticle

Mitnick, CD, White, RA, Lu, C, Rodriguez, CA, Bayona, J, Becerra, MC, Burgos, M, Centis, R, Cohen, T, Cox, H, D'Ambrosio, L, Danilovitz, M, Falzon, D, Gelmanova, IY, Gler, MT, Grinsdale, JA, Holtz, TH, Keshavjee, S, Leimane, V, Menzies, D, Migliori, GB, Milstein, MB, Mishustin, SP, Pagano, M, Quelapio, MI, Shean, K, Shin, SS, Tolman, AW, Van Der Walt, ML, Van Deun, A, Viiklepp, P, Ahuja, SD, Andreev, YG, Ashkin, D, Avendano, M, Banerjee, R, Bauer, M, Benedetti, A, Brand, J, Chan, ED, Chiang, CY, DeRiemer, K, Dung, NH, Enarson, D, Flanagan, K, Flood, J, Garcia-Garcia, ML, Gandhi, N, Granich, RM, Hollm-Delgado, MG, Iseman, MD, Jarlsberg, LG, Kim, HR, Koh, WJ, Lancaster, J, Lange, C, De Lange, WCM, Leung, CC, Li, J, Maug, AKJ, Narita, M, Odendaal, R, O'Riordan, P, Pai, M, Palmero, D, Seung-Kyu, Pasvol, G, Peña, J, Pérez-Guzmán, C, Ponce-De-Leon, A, Riekstina, V, Robert, J, Royce, S, Schaaf, HS, Seung, KJ, Shah, L, Shim, TS, Shiraishi, Y, Sifuentes-Osornio, J, Strand, MJ, Shaheed, PT, Tupasi, TE, Van Altena, R, Van Der Werf, TS, Vargas, MH, Westenhouse, J, Yew, WW & Yim, JJ 2016, 'Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method', European Respiratory Journal, vol. 48, no. 4, pp. 1160-1170. https://doi.org/10.1183/13993003.00462-2016
Mitnick, Carole D. ; White, Richard A. ; Lu, Chunling ; Rodriguez, Carly A. ; Bayona, Jaime ; Becerra, Mercedes C. ; Burgos, Marcos ; Centis, Rosella ; Cohen, Theodore ; Cox, Helen ; D'Ambrosio, Lia ; Danilovitz, Manfred ; Falzon, Dennis ; Gelmanova, Irina Y. ; Gler, Maria T. ; Grinsdale, Jennifer A. ; Holtz, Timothy H. ; Keshavjee, Salmaan ; Leimane, Vaira ; Menzies, Dick ; Migliori, Giovanni Battista ; Milstein, Meredith B. ; Mishustin, Sergey P. ; Pagano, Marcello ; Quelapio, Maria I. ; Shean, Karen ; Shin, Sonya S. ; Tolman, Arielle W. ; Van Der Walt, Martha L. ; Van Deun, Armand ; Viiklepp, Piret ; Ahuja, Shama D. ; Andreev, Yevgeny G. ; Ashkin, David ; Avendano, Monika ; Banerjee, Rita ; Bauer, Melissa ; Benedetti, Andrea ; Brand, Jeannette ; Chan, Edward D. ; Chiang, Chen Yuan ; DeRiemer, Kathy ; Dung, Nguyen Huy ; Enarson, Donald ; Flanagan, Katherine ; Flood, Jennifer ; Garcia-Garcia, Maria L. ; Gandhi, Neel ; Granich, Reuben M. ; Hollm-Delgado, Maria G. ; Iseman, Michael D. ; Jarlsberg, Leah G. ; Kim, Hye Ryoun ; Koh, Won Jung ; Lancaster, Joey ; Lange, Christophe ; De Lange, Wiel C M ; Leung, Chi Chiu ; Li, Jiehui ; Maug, Aung Kya Jai ; Narita, Masa ; Odendaal, Ronel ; O'Riordan, Philly ; Pai, Madhukar ; Palmero, Domingo ; Seung-Kyu ; Pasvol, Geoffrey ; Peña, Jose ; Pérez-Guzmán, Carlos ; Ponce-De-Leon, Alfredo ; Riekstina, Vija ; Robert, Jerome ; Royce, Sarah ; Schaaf, H. Simon ; Seung, Kwonjune J. ; Shah, Lena ; Shim, Tae Sun ; Shiraishi, Yuji ; Sifuentes-Osornio, José ; Strand, Matthew J. ; Shaheed, Payam Tabarsi ; Tupasi, Thelma E. ; Van Altena, Robert ; Van Der Werf, Tjip S. ; Vargas, Mario H. ; Westenhouse, Janice ; Yew, Wing Wai ; Yim, Jae Joon. / Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method. In: European Respiratory Journal. 2016 ; Vol. 48, No. 4. pp. 1160-1170.
@article{218880bd473a41728609d094c56397ff,
title = "Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method",
abstract = "Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of monitoring strategies on timing of failure detection. We identified studies reporting microbiological response to MDR-TB treatment and solicited individual patient data from authors. Frailty survival models were used to estimate pooled relative risk of failure detection in the last 12 months of treatment; hazard of failure using monthly culture was the reference. Data were obtained for 5410 patients across 12 observational studies. During the last 12 months of treatment, failure detection occurred in a median of 3 months by monthly culture; failure detection was delayed by 2, 7, and 9 months relying on bimonthly culture, monthly smear and bimonthly smear, respectively. Risk (95{\%} CI) of failure detection delay resulting from monthly smear relative to culture is 0.38 (0.34-0.42) for all patients and 0.33 (0.25-0.42) for HIV-co-infected patients. Failure detection is delayed by reducing the sensitivity and frequency of the monitoring method. Monthly monitoring of sputum cultures from patients receiving MDR-TB treatment is recommended. Expanded laboratory capacity is needed for high-quality culture, and for smear microscopy and rapid molecular tests.",
author = "Mitnick, {Carole D.} and White, {Richard A.} and Chunling Lu and Rodriguez, {Carly A.} and Jaime Bayona and Becerra, {Mercedes C.} and Marcos Burgos and Rosella Centis and Theodore Cohen and Helen Cox and Lia D'Ambrosio and Manfred Danilovitz and Dennis Falzon and Gelmanova, {Irina Y.} and Gler, {Maria T.} and Grinsdale, {Jennifer A.} and Holtz, {Timothy H.} and Salmaan Keshavjee and Vaira Leimane and Dick Menzies and Migliori, {Giovanni Battista} and Milstein, {Meredith B.} and Mishustin, {Sergey P.} and Marcello Pagano and Quelapio, {Maria I.} and Karen Shean and Shin, {Sonya S.} and Tolman, {Arielle W.} and {Van Der Walt}, {Martha L.} and {Van Deun}, Armand and Piret Viiklepp and Ahuja, {Shama D.} and Andreev, {Yevgeny G.} and David Ashkin and Monika Avendano and Rita Banerjee and Melissa Bauer and Andrea Benedetti and Jeannette Brand and Chan, {Edward D.} and Chiang, {Chen Yuan} and Kathy DeRiemer and Dung, {Nguyen Huy} and Donald Enarson and Katherine Flanagan and Jennifer Flood and Garcia-Garcia, {Maria L.} and Neel Gandhi and Granich, {Reuben M.} and Hollm-Delgado, {Maria G.} and Iseman, {Michael D.} and Jarlsberg, {Leah G.} and Kim, {Hye Ryoun} and Koh, {Won Jung} and Joey Lancaster and Christophe Lange and {De Lange}, {Wiel C M} and Leung, {Chi Chiu} and Jiehui Li and Maug, {Aung Kya Jai} and Masa Narita and Ronel Odendaal and Philly O'Riordan and Madhukar Pai and Domingo Palmero and Seung-Kyu and Geoffrey Pasvol and Jose Pe{\~n}a and Carlos P{\'e}rez-Guzm{\'a}n and Alfredo Ponce-De-Leon and Vija Riekstina and Jerome Robert and Sarah Royce and Schaaf, {H. Simon} and Seung, {Kwonjune J.} and Lena Shah and Shim, {Tae Sun} and Yuji Shiraishi and Jos{\'e} Sifuentes-Osornio and Strand, {Matthew J.} and Shaheed, {Payam Tabarsi} and Tupasi, {Thelma E.} and {Van Altena}, Robert and {Van Der Werf}, {Tjip S.} and Vargas, {Mario H.} and Janice Westenhouse and Yew, {Wing Wai} and Yim, {Jae Joon}",
year = "2016",
month = "10",
day = "1",
doi = "10.1183/13993003.00462-2016",
language = "English",
volume = "48",
pages = "1160--1170",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "4",

}

TY - JOUR

T1 - Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method

AU - Mitnick, Carole D.

AU - White, Richard A.

AU - Lu, Chunling

AU - Rodriguez, Carly A.

AU - Bayona, Jaime

AU - Becerra, Mercedes C.

AU - Burgos, Marcos

AU - Centis, Rosella

AU - Cohen, Theodore

AU - Cox, Helen

AU - D'Ambrosio, Lia

AU - Danilovitz, Manfred

AU - Falzon, Dennis

AU - Gelmanova, Irina Y.

AU - Gler, Maria T.

AU - Grinsdale, Jennifer A.

AU - Holtz, Timothy H.

AU - Keshavjee, Salmaan

AU - Leimane, Vaira

AU - Menzies, Dick

AU - Migliori, Giovanni Battista

AU - Milstein, Meredith B.

AU - Mishustin, Sergey P.

AU - Pagano, Marcello

AU - Quelapio, Maria I.

AU - Shean, Karen

AU - Shin, Sonya S.

AU - Tolman, Arielle W.

AU - Van Der Walt, Martha L.

AU - Van Deun, Armand

AU - Viiklepp, Piret

AU - Ahuja, Shama D.

AU - Andreev, Yevgeny G.

AU - Ashkin, David

AU - Avendano, Monika

AU - Banerjee, Rita

AU - Bauer, Melissa

AU - Benedetti, Andrea

AU - Brand, Jeannette

AU - Chan, Edward D.

AU - Chiang, Chen Yuan

AU - DeRiemer, Kathy

AU - Dung, Nguyen Huy

AU - Enarson, Donald

AU - Flanagan, Katherine

AU - Flood, Jennifer

AU - Garcia-Garcia, Maria L.

AU - Gandhi, Neel

AU - Granich, Reuben M.

AU - Hollm-Delgado, Maria G.

AU - Iseman, Michael D.

AU - Jarlsberg, Leah G.

AU - Kim, Hye Ryoun

AU - Koh, Won Jung

AU - Lancaster, Joey

AU - Lange, Christophe

AU - De Lange, Wiel C M

AU - Leung, Chi Chiu

AU - Li, Jiehui

AU - Maug, Aung Kya Jai

AU - Narita, Masa

AU - Odendaal, Ronel

AU - O'Riordan, Philly

AU - Pai, Madhukar

AU - Palmero, Domingo

AU - Seung-Kyu,

AU - Pasvol, Geoffrey

AU - Peña, Jose

AU - Pérez-Guzmán, Carlos

AU - Ponce-De-Leon, Alfredo

AU - Riekstina, Vija

AU - Robert, Jerome

AU - Royce, Sarah

AU - Schaaf, H. Simon

AU - Seung, Kwonjune J.

AU - Shah, Lena

AU - Shim, Tae Sun

AU - Shiraishi, Yuji

AU - Sifuentes-Osornio, José

AU - Strand, Matthew J.

AU - Shaheed, Payam Tabarsi

AU - Tupasi, Thelma E.

AU - Van Altena, Robert

AU - Van Der Werf, Tjip S.

AU - Vargas, Mario H.

AU - Westenhouse, Janice

AU - Yew, Wing Wai

AU - Yim, Jae Joon

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of monitoring strategies on timing of failure detection. We identified studies reporting microbiological response to MDR-TB treatment and solicited individual patient data from authors. Frailty survival models were used to estimate pooled relative risk of failure detection in the last 12 months of treatment; hazard of failure using monthly culture was the reference. Data were obtained for 5410 patients across 12 observational studies. During the last 12 months of treatment, failure detection occurred in a median of 3 months by monthly culture; failure detection was delayed by 2, 7, and 9 months relying on bimonthly culture, monthly smear and bimonthly smear, respectively. Risk (95% CI) of failure detection delay resulting from monthly smear relative to culture is 0.38 (0.34-0.42) for all patients and 0.33 (0.25-0.42) for HIV-co-infected patients. Failure detection is delayed by reducing the sensitivity and frequency of the monitoring method. Monthly monitoring of sputum cultures from patients receiving MDR-TB treatment is recommended. Expanded laboratory capacity is needed for high-quality culture, and for smear microscopy and rapid molecular tests.

AB - Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of monitoring strategies on timing of failure detection. We identified studies reporting microbiological response to MDR-TB treatment and solicited individual patient data from authors. Frailty survival models were used to estimate pooled relative risk of failure detection in the last 12 months of treatment; hazard of failure using monthly culture was the reference. Data were obtained for 5410 patients across 12 observational studies. During the last 12 months of treatment, failure detection occurred in a median of 3 months by monthly culture; failure detection was delayed by 2, 7, and 9 months relying on bimonthly culture, monthly smear and bimonthly smear, respectively. Risk (95% CI) of failure detection delay resulting from monthly smear relative to culture is 0.38 (0.34-0.42) for all patients and 0.33 (0.25-0.42) for HIV-co-infected patients. Failure detection is delayed by reducing the sensitivity and frequency of the monitoring method. Monthly monitoring of sputum cultures from patients receiving MDR-TB treatment is recommended. Expanded laboratory capacity is needed for high-quality culture, and for smear microscopy and rapid molecular tests.

UR - http://www.scopus.com/inward/record.url?scp=84990051246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990051246&partnerID=8YFLogxK

U2 - 10.1183/13993003.00462-2016

DO - 10.1183/13993003.00462-2016

M3 - Article

AN - SCOPUS:84990051246

VL - 48

SP - 1160

EP - 1170

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 4

ER -