Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma

Chun Hsiung Chen, Chih Hsueh Chen, Horng An Chen, Hsien Tzung Liao, Hsiao Yi Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Multicentric reticulohistiocytosis (MRH) is a rare multisystemic disease presenting with skin lesions and erosive polyarthritis and is often associated with malignancy. We describe a 60-year-old woman with diffuse papulonodular skin eruptions and progressive osteolytic bone damage over the bilateral hands, humeral head, and acromioclavicular joints within 2 years. Moreover, dysphagia and a hoarse voice occurred in this patient and an unusual huge mass-reticulohistiocytoma-developed over the left upper back. Tissue biopsy of the skin lesions, laryngeal nodules, and this large mass showed infiltration of numerous CD68(+) histiocytes and multinucleated giant cells with abundant eosinophilic ground-glass cytoplasm. Combination therapy with steroids and methotrexate improved her cutaneous, joint, and laryngopharyngeal symptoms. The large reticulohistiocytoma resolved with methylprednisolone pulse therapy. This polyarthritis, which can be confused with rheumatoid arthritis, can be diagnosed by careful immunohistochemical examination of biopsies. To prevent the irreversible disease process, early and aggressive therapy is necessary.

Original languageEnglish
Pages (from-to)252-254
Number of pages3
JournalJournal of Clinical Rheumatology
Volume12
Issue number5
DOIs
Publication statusPublished - Oct 2006

Fingerprint

Non-Langerhans-Cell Histiocytosis
Arthritis
Skin
Acromioclavicular Joint
Humeral Head
Biopsy
Histiocytes
Methylprednisolone
Giant Cells
Deglutition Disorders
Rare Diseases
Secondary Prevention
Methotrexate
Glass
Rheumatoid Arthritis
Cytoplasm
Hand
Joints
Steroids
Bone and Bones

Keywords

  • Multicentric reticulohistiocytosis
  • Nasopharyngeal dysfunction
  • Polyarthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma. / Chen, Chun Hsiung; Chen, Chih Hsueh; Chen, Horng An; Liao, Hsien Tzung; Lin, Hsiao Yi.

In: Journal of Clinical Rheumatology, Vol. 12, No. 5, 10.2006, p. 252-254.

Research output: Contribution to journalArticle

Chen, Chun Hsiung ; Chen, Chih Hsueh ; Chen, Horng An ; Liao, Hsien Tzung ; Lin, Hsiao Yi. / Multicentric reticulohistiocytosis presenting with destructive polyarthritis, laryngopharyngeal dysfunction, and a huge reticulohistiocytoma. In: Journal of Clinical Rheumatology. 2006 ; Vol. 12, No. 5. pp. 252-254.
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