Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants

Pei I. Tsai, Tu Ngoc Lam, Meng Huang Wu, Kuan Ying Tseng, Yuan Wei Chang, Jui Sheng Sun, Yen Yao Li, Ming Hsueh Lee, San Yuan Chen, Chung Kai Chang, Chun Jen Su, Chia Hsien Lin, Ching Yu Chiang, Ching Shun Ku, Nien Ti Tsou, Shao Ju Shih, Chun Chieh Wang, E. Wen Huang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti–6Al–4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti–6Al–4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti–6Al–4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti–6Al–4V pores enhance the collagen-regulated mineralization.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalMaterials Chemistry and Physics
Volume230
DOIs
Publication statusPublished - May 15 2019

Fingerprint

3D printers
collagens
Collagen
bones
Bone
manufacturing
crystallinity
Titanium
titanium
osteogenesis
x rays
Tantalum
X rays
Vanadium
tantalum
Wave transmission
vanadium
crystallites
Durapatite
Aluminum

Keywords

  • Additive manufacturing
  • Implant
  • Nano X-ray Laue diffraction mapping
  • Small X-ray angle scattering
  • X-ray tomography

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants. / Tsai, Pei I.; Lam, Tu Ngoc; Wu, Meng Huang; Tseng, Kuan Ying; Chang, Yuan Wei; Sun, Jui Sheng; Li, Yen Yao; Lee, Ming Hsueh; Chen, San Yuan; Chang, Chung Kai; Su, Chun Jen; Lin, Chia Hsien; Chiang, Ching Yu; Ku, Ching Shun; Tsou, Nien Ti; Shih, Shao Ju; Wang, Chun Chieh; Huang, E. Wen.

In: Materials Chemistry and Physics, Vol. 230, 15.05.2019, p. 83-92.

Research output: Contribution to journalArticle

Tsai, PI, Lam, TN, Wu, MH, Tseng, KY, Chang, YW, Sun, JS, Li, YY, Lee, MH, Chen, SY, Chang, CK, Su, CJ, Lin, CH, Chiang, CY, Ku, CS, Tsou, NT, Shih, SJ, Wang, CC & Huang, EW 2019, 'Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants', Materials Chemistry and Physics, vol. 230, pp. 83-92. https://doi.org/10.1016/j.matchemphys.2019.03.047
Tsai, Pei I. ; Lam, Tu Ngoc ; Wu, Meng Huang ; Tseng, Kuan Ying ; Chang, Yuan Wei ; Sun, Jui Sheng ; Li, Yen Yao ; Lee, Ming Hsueh ; Chen, San Yuan ; Chang, Chung Kai ; Su, Chun Jen ; Lin, Chia Hsien ; Chiang, Ching Yu ; Ku, Ching Shun ; Tsou, Nien Ti ; Shih, Shao Ju ; Wang, Chun Chieh ; Huang, E. Wen. / Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants. In: Materials Chemistry and Physics. 2019 ; Vol. 230. pp. 83-92.
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