Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice

Xiu Min Li, Rajesh K. Chopra, Teh Ying Chou, Brian H. Schofield, Marsha Wills-Karp, Shau Ku Huang

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Abstract

Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-γ gene transfer results in a significant expression of IFN-γ in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-γ gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach.

Original languageEnglish
Pages (from-to)3216-3219
Number of pages4
JournalJournal of Immunology
Volume157
Issue number8
Publication statusPublished - Oct 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Li, X. M., Chopra, R. K., Chou, T. Y., Schofield, B. H., Wills-Karp, M., & Huang, S. K. (1996). Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. Journal of Immunology, 157(8), 3216-3219.