Abstract
Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-γ gene transfer results in a significant expression of IFN-γ in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-γ gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach.
| Original language | English |
|---|---|
| Pages (from-to) | 3216-3219 |
| Number of pages | 4 |
| Journal | Journal of Immunology |
| Volume | 157 |
| Issue number | 8 |
| Publication status | Published - Oct 15 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. / Li, Xiu Min; Chopra, Rajesh K.; Chou, Teh Ying; Schofield, Brian H.; Wills-Karp, Marsha; Huang, Shau Ku.
In: Journal of Immunology, Vol. 157, No. 8, 15.10.1996, p. 3216-3219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice
AU - Li, Xiu Min
AU - Chopra, Rajesh K.
AU - Chou, Teh Ying
AU - Schofield, Brian H.
AU - Wills-Karp, Marsha
AU - Huang, Shau Ku
PY - 1996/10/15
Y1 - 1996/10/15
N2 - Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-γ gene transfer results in a significant expression of IFN-γ in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-γ gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach.
AB - Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-γ gene transfer results in a significant expression of IFN-γ in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-γ gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030587861&partnerID=8YFLogxK
M3 - Article
C2 - 8871613
AN - SCOPUS:0030587861
VL - 157
SP - 3216
EP - 3219
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 8
ER -