Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice

Xiu Min Li, Rajesh K. Chopra, Teh Ying Chou, Brian H. Schofield, Marsha Wills-Karp, Shau Ku Huang

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-γ gene transfer results in a significant expression of IFN-γ in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-γ gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach.

Original languageEnglish
Pages (from-to)3216-3219
Number of pages4
JournalJournal of Immunology
Volume157
Issue number8
Publication statusPublished - Oct 15 1996
Externally publishedYes

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Lung
Asthma
Pulmonary Eosinophilia
Cytokines
Genes
Th2 Cells
Epithelium
Inflammation
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Li, X. M., Chopra, R. K., Chou, T. Y., Schofield, B. H., Wills-Karp, M., & Huang, S. K. (1996). Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. Journal of Immunology, 157(8), 3216-3219.

Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. / Li, Xiu Min; Chopra, Rajesh K.; Chou, Teh Ying; Schofield, Brian H.; Wills-Karp, Marsha; Huang, Shau Ku.

In: Journal of Immunology, Vol. 157, No. 8, 15.10.1996, p. 3216-3219.

Research output: Contribution to journalArticle

Li, XM, Chopra, RK, Chou, TY, Schofield, BH, Wills-Karp, M & Huang, SK 1996, 'Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice', Journal of Immunology, vol. 157, no. 8, pp. 3216-3219.
Li XM, Chopra RK, Chou TY, Schofield BH, Wills-Karp M, Huang SK. Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. Journal of Immunology. 1996 Oct 15;157(8):3216-3219.
Li, Xiu Min ; Chopra, Rajesh K. ; Chou, Teh Ying ; Schofield, Brian H. ; Wills-Karp, Marsha ; Huang, Shau Ku. / Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. In: Journal of Immunology. 1996 ; Vol. 157, No. 8. pp. 3216-3219.
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