Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery: Effect of formulation variables on drug release and mucoadhesive performance

Rough Yee Han, Jia You Fang, K. C. Sung, Oliver Y P Hu

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The objective of this work was to assess the effects of drug solubility and loading percent, as well as Carbopol 934/hydroxypropylcellulose (CP/HPC) ratio, on drug release and mucoadhesive performance of the nalbuphine prodrug loaded buccal disks. Drug release rates for the disks were found to be a function of drug solubility, with higher drug release rates for disks loaded with more hydrophilic prodrugs and an increased amount of β-cyclodextrin. The drug release rates increased with loading percents for nalbuphine hydrochloride, whereas an opposite drug release trend was observed for disks loaded with nalbuphine enanthate, which can be explained by the diffusional drug release mechanism. The CP/HPC ratio affected release rates of nalbuphine enanthate, whereas the ratio had no impact on the release of nalbuphine hydrochloride. Within the 2 days of experiment time, all formulations attached well to the porcine buccal tissues, indicating those formulation variables had no influence on the mucoadhesive performance of CP/HPC-based buccal disks.

Original languageEnglish
Pages (from-to)201-209
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume177
Issue number2
DOIs
Publication statusPublished - Jan 25 1999
Externally publishedYes

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Keywords

  • Buccal disk
  • Controlled release
  • Drug release
  • Mucoadhesion
  • Nalbuphine prodrug

ASJC Scopus subject areas

  • Pharmaceutical Science

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