Mucin expression in mucinous carcinoma and other invasive carcinomas of the breast

Jan Show Chu, King Jen Chang

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

To investigate mucin expression in breast cancer, immunohistochemical staining was performed on 30 mucinous carcinomas and 95 non-mucinous invasive carcinomas. MUC2 expression was detected in all mucinous carcinomas, but only in 11.1% of invasive ductal carcinomas, and in none of the invasive lobular carcinomas and medullary carcinomas. MUC1 is often expressed in invasive breast carcinoma, but not in medullary carcinoma. Strong cytoplasmic staining was seen in invasive ductal carcinoma, in contrast to surface membrane staining in mucinous carcinoma and intracytoplasmic vacuole staining in invasive lobular carcinoma. CA19-9 and CA50 expression in more than 25% of tumor cells was seen in 17.2 and 16.0% of invasive ductal carcinomas, respectively, but not in mucinous carcinomas. CA125 and human gastric mucin were rarely expressed in breast cancer, irrespective of histologic type. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalCancer Letters
Volume142
Issue number1
DOIs
Publication statusPublished - Jul 19 1999

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Keywords

  • Breast cancer
  • MUC1
  • MUC2
  • Mucin
  • Mucinous carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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