MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan

Chih Ching Yeh, Ling Ling Hsieh, Reiping Tang, Chung Rong Chang-Chieh, Fung Chang Sung

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

This hospital-based case-control study examined whether polymorphic DNA repair genes: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, play a role in the susceptibility to colorectal cancer. We genotyped these polymorphisms for 727 newly diagnosed colorectal adenocarcinoma cases and 736 age and sex matched healthy controls in Taiwan. Although the colorectal cancer risk was not significantly associated with these genes, the risk was significantly elevated in younger subjects (≤60 years) with the XRCC1 399Arg/Arg genotype compared to those with XRCC1 399Gln allele (OR=1.46, 95% CI=1.06-2.99, P=0.02). The stratified analysis showed that XRCC3 interacted with meat consumption (P for interaction=0.02), but was limited to the low meat consumption (OR=2.34, 95% CI=1.28-4.29). Our results suggest that the XRCC1 Arg399Gln polymorphism may contribute to the risk of early-onset colorectal cancer and the XRCC3 Thr241Met polymorphism may modify the risk for meat-associated colorectal cancer.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalCancer Letters
Volume224
Issue number2
DOIs
Publication statusPublished - Jun 28 2005
Externally publishedYes

Keywords

  • Colorectal cancer
  • Diet
  • Polymorphisms
  • XPD
  • XRCC1
  • XRCC3

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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