MR of the cerebral operculum: Abnormal opercular formation in infants and children

Cheng Yu Chen, Robert A. Zimmerman, Scott Faro, Beth Parrish, Zhiyue Wang, Larissa T. Bilaniuk, Ting Ywan Chou

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

PURPOSE: To evaluate abnormalities of the cerebral operculum in infants and children and to propose the embryogenic basis of abnormal opercular formation as determined from MR imaging findings. METHODS: Eighty-six infants and children who had abnormally wide interopercular distances and/or distorted opercular topography seen on MR images were studied retrospectively. Clinically, patients presented with tonal abnormalities, macrocephaly, microcephaly, seizures, developmental delay, cerebral palsy, or facial dysmorphism. The abnormal opercula were compared with developing opercula at different stages of gestation. RESULTS: Among the 86 infants and children, two categories of opercular abnormalities were identified: an underdeveloped operculum (n = 64) and a malformed operculum (n = 22). The malformed operculum was further classified into three subtypes: nonformation of the operculum with lissencephaly (n = 1, 1%), abnormal opercular formation with pachygyria (n = 11, 13%), and nonformation or abnormal formation of the operculum without pachygyria or lissencephaly (n = 10, 12%). Two subtypes of the underdeveloped operculum were identified: an open operculum without a normal insula (n = 6, 7%) and an open operculum with a normal insula (n = 58, 67%). The five subtypes of abnormal opercular configuration showed a range of maturity that was comparable to the developing operculum at different ages. CONCLUSION: Opercular anomalies appear to follow sequentially predetermined normal steps in development. Arrest in opercular development or malformation may occur after an initial insult. MR imaging is the method of choice by which to identify these abnormalities.

Original languageEnglish
Pages (from-to)1303-1311
Number of pages9
JournalAmerican Journal of Neuroradiology
Volume17
Issue number7
Publication statusPublished - Aug 1996
Externally publishedYes

Fingerprint

Lissencephaly
Classical Lissencephalies and Subcortical Band Heterotopias
Megalencephaly
Microcephaly
Cerebral Palsy
Seizures
Pregnancy

Keywords

  • Brain, abnormalities and anomalies
  • Brain, growth and development
  • Brain, magnetic resonance

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Chen, C. Y., Zimmerman, R. A., Faro, S., Parrish, B., Wang, Z., Bilaniuk, L. T., & Chou, T. Y. (1996). MR of the cerebral operculum: Abnormal opercular formation in infants and children. American Journal of Neuroradiology, 17(7), 1303-1311.

MR of the cerebral operculum : Abnormal opercular formation in infants and children. / Chen, Cheng Yu; Zimmerman, Robert A.; Faro, Scott; Parrish, Beth; Wang, Zhiyue; Bilaniuk, Larissa T.; Chou, Ting Ywan.

In: American Journal of Neuroradiology, Vol. 17, No. 7, 08.1996, p. 1303-1311.

Research output: Contribution to journalArticle

Chen, CY, Zimmerman, RA, Faro, S, Parrish, B, Wang, Z, Bilaniuk, LT & Chou, TY 1996, 'MR of the cerebral operculum: Abnormal opercular formation in infants and children', American Journal of Neuroradiology, vol. 17, no. 7, pp. 1303-1311.
Chen CY, Zimmerman RA, Faro S, Parrish B, Wang Z, Bilaniuk LT et al. MR of the cerebral operculum: Abnormal opercular formation in infants and children. American Journal of Neuroradiology. 1996 Aug;17(7):1303-1311.
Chen, Cheng Yu ; Zimmerman, Robert A. ; Faro, Scott ; Parrish, Beth ; Wang, Zhiyue ; Bilaniuk, Larissa T. ; Chou, Ting Ywan. / MR of the cerebral operculum : Abnormal opercular formation in infants and children. In: American Journal of Neuroradiology. 1996 ; Vol. 17, No. 7. pp. 1303-1311.
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abstract = "PURPOSE: To evaluate abnormalities of the cerebral operculum in infants and children and to propose the embryogenic basis of abnormal opercular formation as determined from MR imaging findings. METHODS: Eighty-six infants and children who had abnormally wide interopercular distances and/or distorted opercular topography seen on MR images were studied retrospectively. Clinically, patients presented with tonal abnormalities, macrocephaly, microcephaly, seizures, developmental delay, cerebral palsy, or facial dysmorphism. The abnormal opercula were compared with developing opercula at different stages of gestation. RESULTS: Among the 86 infants and children, two categories of opercular abnormalities were identified: an underdeveloped operculum (n = 64) and a malformed operculum (n = 22). The malformed operculum was further classified into three subtypes: nonformation of the operculum with lissencephaly (n = 1, 1{\%}), abnormal opercular formation with pachygyria (n = 11, 13{\%}), and nonformation or abnormal formation of the operculum without pachygyria or lissencephaly (n = 10, 12{\%}). Two subtypes of the underdeveloped operculum were identified: an open operculum without a normal insula (n = 6, 7{\%}) and an open operculum with a normal insula (n = 58, 67{\%}). The five subtypes of abnormal opercular configuration showed a range of maturity that was comparable to the developing operculum at different ages. CONCLUSION: Opercular anomalies appear to follow sequentially predetermined normal steps in development. Arrest in opercular development or malformation may occur after an initial insult. MR imaging is the method of choice by which to identify these abnormalities.",
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