Moving toward personalized medicine in the methadone maintenance treatment program: A pilot study on the evaluation of treatment responses in Taiwan

Hsin Ya Lee, Jih Heng Li, Yuh Ling Sheu, Hsin Pei Tang, Wei Chiao Chang, Tze Chun Tang, Yi Chun Yeh, Shing Yaw Wang, Ray H. Liu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.

Original languageEnglish
Article number741403
JournalBioMed Research International
Volume2013
DOIs
Publication statusPublished - 2013

Fingerprint

Precision Medicine
Methadone
Taiwan
Medicine
Drug interactions
Therapeutics
National Health Programs
Drug Interactions
Alleles
Health insurance
Genetic Polymorphisms
Polymorphism
Coinfection
Metabolism
Psychiatry
Alcohols
Demography
Plasmas

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Moving toward personalized medicine in the methadone maintenance treatment program : A pilot study on the evaluation of treatment responses in Taiwan. / Lee, Hsin Ya; Li, Jih Heng; Sheu, Yuh Ling; Tang, Hsin Pei; Chang, Wei Chiao; Tang, Tze Chun; Yeh, Yi Chun; Wang, Shing Yaw; Liu, Ray H.

In: BioMed Research International, Vol. 2013, 741403, 2013.

Research output: Contribution to journalArticle

Lee, Hsin Ya ; Li, Jih Heng ; Sheu, Yuh Ling ; Tang, Hsin Pei ; Chang, Wei Chiao ; Tang, Tze Chun ; Yeh, Yi Chun ; Wang, Shing Yaw ; Liu, Ray H. / Moving toward personalized medicine in the methadone maintenance treatment program : A pilot study on the evaluation of treatment responses in Taiwan. In: BioMed Research International. 2013 ; Vol. 2013.
@article{04b1a9758d6342e79ca5fd054267589e,
title = "Moving toward personalized medicine in the methadone maintenance treatment program: A pilot study on the evaluation of treatment responses in Taiwan",
abstract = "This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.",
author = "Lee, {Hsin Ya} and Li, {Jih Heng} and Sheu, {Yuh Ling} and Tang, {Hsin Pei} and Chang, {Wei Chiao} and Tang, {Tze Chun} and Yeh, {Yi Chun} and Wang, {Shing Yaw} and Liu, {Ray H.}",
year = "2013",
doi = "10.1155/2013/741403",
language = "English",
volume = "2013",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Moving toward personalized medicine in the methadone maintenance treatment program

T2 - A pilot study on the evaluation of treatment responses in Taiwan

AU - Lee, Hsin Ya

AU - Li, Jih Heng

AU - Sheu, Yuh Ling

AU - Tang, Hsin Pei

AU - Chang, Wei Chiao

AU - Tang, Tze Chun

AU - Yeh, Yi Chun

AU - Wang, Shing Yaw

AU - Liu, Ray H.

PY - 2013

Y1 - 2013

N2 - This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.

AB - This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.

UR - http://www.scopus.com/inward/record.url?scp=84893780211&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893780211&partnerID=8YFLogxK

U2 - 10.1155/2013/741403

DO - 10.1155/2013/741403

M3 - Article

C2 - 24455721

AN - SCOPUS:84893780211

VL - 2013

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 741403

ER -