Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

An Chi Tsai, Shiow Lin Pan, Cho Hwa Liao, Jih Hwa Guh, Shih Wei Wang, Hui Lung Sun, Yi Nan Liu, Chien Chih Chen, Chien Chang Shen, Ya Ling Chang, Che Ming Teng

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45 Citations (Scopus)

Abstract

Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalCancer Letters
Volume292
Issue number2
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Angiogenesis
  • BFGF
  • Endothelial cells
  • Moscatilin
  • VEGF

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Tsai, A. C., Pan, S. L., Liao, C. H., Guh, J. H., Wang, S. W., Sun, H. L., Liu, Y. N., Chen, C. C., Shen, C. C., Chang, Y. L., & Teng, C. M. (2010). Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo. Cancer Letters, 292(2), 163-170. https://doi.org/10.1016/j.canlet.2009.11.020